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Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers
Understanding viral tropism is an essential step toward reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, decreasing mortality from coronavirus disease 2019 (COVID-19) and limiting opportunities for mutant strains to arise. Currently, little is known about the exten...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479532/ https://www.ncbi.nlm.nih.gov/pubmed/34604819 http://dx.doi.org/10.1016/j.xcrm.2021.100421 |
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author | Nakayama, Tsuguhisa Lee, Ivan T. Jiang, Sizun Matter, Matthias S. Yan, Carol H. Overdevest, Jonathan B. Wu, Chien-Ting Goltsev, Yury Shih, Liang-Chun Liao, Chun-Kang Zhu, Bokai Bai, Yunhao Lidsky, Peter Xiao, Yinghong Zarabanda, David Yang, Angela Easwaran, Meena Schürch, Christian M. Chu, Pauline Chen, Han Stalder, Anna K. McIlwain, David R. Borchard, Nicole A. Gall, Phillip A. Dholakia, Sachi S. Le, Wei Xu, Le Tai, Chih-Jaan Yeh, Te-Huei Erickson-Direnzo, Elizabeth Duran, Jason M. Mertz, Kirsten D. Hwang, Peter H. Haslbauer, Jasmin D. Jackson, Peter K. Menter, Thomas Andino, Raul Canoll, Peter D. DeConde, Adam S. Patel, Zara M. Tzankov, Alexandar Nolan, Garry P. Nayak, Jayakar V. |
author_facet | Nakayama, Tsuguhisa Lee, Ivan T. Jiang, Sizun Matter, Matthias S. Yan, Carol H. Overdevest, Jonathan B. Wu, Chien-Ting Goltsev, Yury Shih, Liang-Chun Liao, Chun-Kang Zhu, Bokai Bai, Yunhao Lidsky, Peter Xiao, Yinghong Zarabanda, David Yang, Angela Easwaran, Meena Schürch, Christian M. Chu, Pauline Chen, Han Stalder, Anna K. McIlwain, David R. Borchard, Nicole A. Gall, Phillip A. Dholakia, Sachi S. Le, Wei Xu, Le Tai, Chih-Jaan Yeh, Te-Huei Erickson-Direnzo, Elizabeth Duran, Jason M. Mertz, Kirsten D. Hwang, Peter H. Haslbauer, Jasmin D. Jackson, Peter K. Menter, Thomas Andino, Raul Canoll, Peter D. DeConde, Adam S. Patel, Zara M. Tzankov, Alexandar Nolan, Garry P. Nayak, Jayakar V. |
author_sort | Nakayama, Tsuguhisa |
collection | PubMed |
description | Understanding viral tropism is an essential step toward reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, decreasing mortality from coronavirus disease 2019 (COVID-19) and limiting opportunities for mutant strains to arise. Currently, little is known about the extent to which distinct tissue sites in the human head and neck region and proximal respiratory tract selectively permit SARS-CoV-2 infection and replication. In this translational study, we discover key variabilities in expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2), essential SARS-CoV-2 entry factors, among the mucosal tissues of the human proximal airways. We show that SARS-CoV-2 infection is present in all examined head and neck tissues, with a notable tropism for the nasal cavity and tracheal mucosa. Finally, we uncover an association between smoking and higher SARS-CoV-2 viral infection in the human proximal airway, which may explain the increased susceptibility of smokers to developing severe COVID-19. This is at least partially explained by differences in interferon (IFN)-β1 levels between smokers and non-smokers. |
format | Online Article Text |
id | pubmed-8479532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84795322021-09-29 Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers Nakayama, Tsuguhisa Lee, Ivan T. Jiang, Sizun Matter, Matthias S. Yan, Carol H. Overdevest, Jonathan B. Wu, Chien-Ting Goltsev, Yury Shih, Liang-Chun Liao, Chun-Kang Zhu, Bokai Bai, Yunhao Lidsky, Peter Xiao, Yinghong Zarabanda, David Yang, Angela Easwaran, Meena Schürch, Christian M. Chu, Pauline Chen, Han Stalder, Anna K. McIlwain, David R. Borchard, Nicole A. Gall, Phillip A. Dholakia, Sachi S. Le, Wei Xu, Le Tai, Chih-Jaan Yeh, Te-Huei Erickson-Direnzo, Elizabeth Duran, Jason M. Mertz, Kirsten D. Hwang, Peter H. Haslbauer, Jasmin D. Jackson, Peter K. Menter, Thomas Andino, Raul Canoll, Peter D. DeConde, Adam S. Patel, Zara M. Tzankov, Alexandar Nolan, Garry P. Nayak, Jayakar V. Cell Rep Med Article Understanding viral tropism is an essential step toward reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, decreasing mortality from coronavirus disease 2019 (COVID-19) and limiting opportunities for mutant strains to arise. Currently, little is known about the extent to which distinct tissue sites in the human head and neck region and proximal respiratory tract selectively permit SARS-CoV-2 infection and replication. In this translational study, we discover key variabilities in expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2), essential SARS-CoV-2 entry factors, among the mucosal tissues of the human proximal airways. We show that SARS-CoV-2 infection is present in all examined head and neck tissues, with a notable tropism for the nasal cavity and tracheal mucosa. Finally, we uncover an association between smoking and higher SARS-CoV-2 viral infection in the human proximal airway, which may explain the increased susceptibility of smokers to developing severe COVID-19. This is at least partially explained by differences in interferon (IFN)-β1 levels between smokers and non-smokers. Elsevier 2021-09-28 /pmc/articles/PMC8479532/ /pubmed/34604819 http://dx.doi.org/10.1016/j.xcrm.2021.100421 Text en © 2021. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Nakayama, Tsuguhisa Lee, Ivan T. Jiang, Sizun Matter, Matthias S. Yan, Carol H. Overdevest, Jonathan B. Wu, Chien-Ting Goltsev, Yury Shih, Liang-Chun Liao, Chun-Kang Zhu, Bokai Bai, Yunhao Lidsky, Peter Xiao, Yinghong Zarabanda, David Yang, Angela Easwaran, Meena Schürch, Christian M. Chu, Pauline Chen, Han Stalder, Anna K. McIlwain, David R. Borchard, Nicole A. Gall, Phillip A. Dholakia, Sachi S. Le, Wei Xu, Le Tai, Chih-Jaan Yeh, Te-Huei Erickson-Direnzo, Elizabeth Duran, Jason M. Mertz, Kirsten D. Hwang, Peter H. Haslbauer, Jasmin D. Jackson, Peter K. Menter, Thomas Andino, Raul Canoll, Peter D. DeConde, Adam S. Patel, Zara M. Tzankov, Alexandar Nolan, Garry P. Nayak, Jayakar V. Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers |
title | Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers |
title_full | Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers |
title_fullStr | Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers |
title_full_unstemmed | Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers |
title_short | Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers |
title_sort | determinants of sars-cov-2 entry and replication in airway mucosal tissue and susceptibility in smokers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479532/ https://www.ncbi.nlm.nih.gov/pubmed/34604819 http://dx.doi.org/10.1016/j.xcrm.2021.100421 |
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