TFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts

The correct organization of mitochondrial DNA (mtDNA) in nucleoids and the contacts of mitochondria with the ER play an important role in maintaining the mitochondrial genome distribution within the cell. Mitochondria-associated ER membranes (MAMs) consist of interacting proteins and lipids located...

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Detalles Bibliográficos
Autores principales: Aasumets, Koit, Basikhina, Yuliya, Pohjoismäki, Jaakko L., Goffart, Steffi, Gerhold, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479621/
https://www.ncbi.nlm.nih.gov/pubmed/34622037
http://dx.doi.org/10.1016/j.bbrep.2021.101142

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