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PRISM: recovering cell-type-specific expression profiles from individual composite RNA-seq samples

MOTIVATION: A major challenge in analyzing cancer patient transcriptomes is that the tumors are inherently heterogeneous and evolving. We analyzed 214 bulk RNA samples of a longitudinal, prospective ovarian cancer cohort and found that the sample composition changes systematically due to chemotherap...

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Detalles Bibliográficos
Autores principales:	Häkkinen, Antti, Zhang, Kaiyang, Alkodsi, Amjad, Andersson, Noora, Erkan, Erdogan Pekcan, Dai, Jun, Kaipio, Katja, Lamminen, Tarja, Mansuri, Naziha, Huhtinen, Kaisa, Vähärautio, Anna, Carpén, Olli, Hynninen, Johanna, Hietanen, Sakari, Lehtonen, Rainer, Hautaniemi, Sampsa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479664/ https://www.ncbi.nlm.nih.gov/pubmed/33720334 http://dx.doi.org/10.1093/bioinformatics/btab178

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