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Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue
[Image: see text] Gluing dynamic, wet biological tissue is important in injury treatment yet difficult to achieve. Polymeric adhesives are inconvenient to handle due to rapid cross-linking and can raise biocompatibility concerns. Inorganic nanoparticles adhere weakly to wet surfaces. Herein, an aque...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479763/ https://www.ncbi.nlm.nih.gov/pubmed/34604850 http://dx.doi.org/10.1021/jacsau.1c00193 |
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author | Hao, Lam Tan Park, Sohee Choy, Seunghwan Kim, Young-Min Lee, Seung-Woo Ok, Yong Sik Koo, Jun Mo Hwang, Sung Yeon Hwang, Dong Soo Park, Jeyoung Oh, Dongyeop X. |
author_facet | Hao, Lam Tan Park, Sohee Choy, Seunghwan Kim, Young-Min Lee, Seung-Woo Ok, Yong Sik Koo, Jun Mo Hwang, Sung Yeon Hwang, Dong Soo Park, Jeyoung Oh, Dongyeop X. |
author_sort | Hao, Lam Tan |
collection | PubMed |
description | [Image: see text] Gluing dynamic, wet biological tissue is important in injury treatment yet difficult to achieve. Polymeric adhesives are inconvenient to handle due to rapid cross-linking and can raise biocompatibility concerns. Inorganic nanoparticles adhere weakly to wet surfaces. Herein, an aqueous suspension of guanidinium-functionalized chitin nanoparticles as a biomedical adhesive with biocompatible, hemostatic, and antibacterial properties is developed. It glues porcine skin up to 3000-fold more strongly (30 kPa) than inorganic nanoparticles at the same concentration and adheres at neutral pH, which is unachievable with mussel-inspired adhesives alone. The glue exhibits an instant adhesion (2 min) to fully wet surfaces, and the glued assembly endures one-week underwater immersion. The suspension is lowly viscous and stable, hence sprayable and convenient to store. A nanomechanic study reveals that guanidinium moieties are chaotropic, creating strong, multifaceted noncovalent bonds with proteins: salt bridges comprising ionic attraction and bidentate hydrogen bonding with acidic moieties, cation−π interactions with aromatic moieties, and hydrophobic interactions. The adhesion mechanism provides a blueprint for advanced tissue adhesives. |
format | Online Article Text |
id | pubmed-8479763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-84797632021-09-30 Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue Hao, Lam Tan Park, Sohee Choy, Seunghwan Kim, Young-Min Lee, Seung-Woo Ok, Yong Sik Koo, Jun Mo Hwang, Sung Yeon Hwang, Dong Soo Park, Jeyoung Oh, Dongyeop X. JACS Au [Image: see text] Gluing dynamic, wet biological tissue is important in injury treatment yet difficult to achieve. Polymeric adhesives are inconvenient to handle due to rapid cross-linking and can raise biocompatibility concerns. Inorganic nanoparticles adhere weakly to wet surfaces. Herein, an aqueous suspension of guanidinium-functionalized chitin nanoparticles as a biomedical adhesive with biocompatible, hemostatic, and antibacterial properties is developed. It glues porcine skin up to 3000-fold more strongly (30 kPa) than inorganic nanoparticles at the same concentration and adheres at neutral pH, which is unachievable with mussel-inspired adhesives alone. The glue exhibits an instant adhesion (2 min) to fully wet surfaces, and the glued assembly endures one-week underwater immersion. The suspension is lowly viscous and stable, hence sprayable and convenient to store. A nanomechanic study reveals that guanidinium moieties are chaotropic, creating strong, multifaceted noncovalent bonds with proteins: salt bridges comprising ionic attraction and bidentate hydrogen bonding with acidic moieties, cation−π interactions with aromatic moieties, and hydrophobic interactions. The adhesion mechanism provides a blueprint for advanced tissue adhesives. American Chemical Society 2021-09-08 /pmc/articles/PMC8479763/ /pubmed/34604850 http://dx.doi.org/10.1021/jacsau.1c00193 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Hao, Lam Tan Park, Sohee Choy, Seunghwan Kim, Young-Min Lee, Seung-Woo Ok, Yong Sik Koo, Jun Mo Hwang, Sung Yeon Hwang, Dong Soo Park, Jeyoung Oh, Dongyeop X. Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue |
title | Strong, Multifaceted Guanidinium-Based Adhesion of
Bioorganic Nanoparticles to Wet Biological Tissue |
title_full | Strong, Multifaceted Guanidinium-Based Adhesion of
Bioorganic Nanoparticles to Wet Biological Tissue |
title_fullStr | Strong, Multifaceted Guanidinium-Based Adhesion of
Bioorganic Nanoparticles to Wet Biological Tissue |
title_full_unstemmed | Strong, Multifaceted Guanidinium-Based Adhesion of
Bioorganic Nanoparticles to Wet Biological Tissue |
title_short | Strong, Multifaceted Guanidinium-Based Adhesion of
Bioorganic Nanoparticles to Wet Biological Tissue |
title_sort | strong, multifaceted guanidinium-based adhesion of
bioorganic nanoparticles to wet biological tissue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479763/ https://www.ncbi.nlm.nih.gov/pubmed/34604850 http://dx.doi.org/10.1021/jacsau.1c00193 |
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