Radiation induces NORAD expression to promote ESCC radiotherapy resistance via EEPD1/ATR/Chk1 signalling and by inhibiting pri-miR-199a1 processing and the exosomal transfer of miR-199a-5p

BACKGROUND: Radioresistance, a poorly understood phenomenon, results in the failure of radiotherapy and subsequent local recurrence, threatening a large proportion of patients with ESCC. To date, lncRNAs have been reported to be involved in diverse biological processes, including radioresistance. ME...

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Detalles Bibliográficos
Autores principales: Sun, Yuchen, Wang, Jizhao, Ma, Yuan, Li, Jing, Sun, Xuanzi, Zhao, Xu, Shi, Xiaobo, Hu, Yunfeng, Qu, Fengyi, Zhang, Xiaozhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479908/
https://www.ncbi.nlm.nih.gov/pubmed/34587992
http://dx.doi.org/10.1186/s13046-021-02084-5

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