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virusMED: an atlas of hotspots of viral proteins

Metal binding sites, antigen epitopes and drug binding sites are the hotspots in viral proteins that control how viruses interact with their hosts. virusMED (virus Metal binding sites, Epitopes and Drug binding sites) is a rich internet application based on a database of atomic interactions around h...

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Autores principales: Zhang, HuiHui, Chen, Pei, Ma, Haojie, Woińska, Magdalena, Liu, Dejian, Cooper, David R., Peng, Guo, Peng, Yousong, Deng, Lei, Minor, Wladek, Zheng, Heping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479994/
https://www.ncbi.nlm.nih.gov/pubmed/34614039
http://dx.doi.org/10.1107/S2052252521009076
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author Zhang, HuiHui
Chen, Pei
Ma, Haojie
Woińska, Magdalena
Liu, Dejian
Cooper, David R.
Peng, Guo
Peng, Yousong
Deng, Lei
Minor, Wladek
Zheng, Heping
author_facet Zhang, HuiHui
Chen, Pei
Ma, Haojie
Woińska, Magdalena
Liu, Dejian
Cooper, David R.
Peng, Guo
Peng, Yousong
Deng, Lei
Minor, Wladek
Zheng, Heping
author_sort Zhang, HuiHui
collection PubMed
description Metal binding sites, antigen epitopes and drug binding sites are the hotspots in viral proteins that control how viruses interact with their hosts. virusMED (virus Metal binding sites, Epitopes and Drug binding sites) is a rich internet application based on a database of atomic interactions around hotspots in 7041 experimentally determined viral protein structures. 25306 hotspots from 805 virus strains from 75 virus families were characterized, including influenza, HIV-1 and SARS-CoV-2 viruses. Just as Google Maps organizes and annotates points of interest, virusMED presents the positions of individual hotspots on each viral protein and creates an atlas upon which newly characterized functional sites can be placed as they are being discovered. virusMED contains an extensive set of annotation tags about the virus species and strains, viral hosts, viral proteins, metal ions, specific antibodies and FDA-approved drugs, which permits rapid screening of hotspots on viral proteins tailored to a particular research problem. The virusMED portal (https://virusmed.biocloud.top) can serve as a window to a valuable resource for many areas of virus research and play a critical role in the rational design of new preventative and therapeutic agents targeting viral infections.
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spelling pubmed-84799942021-09-29 virusMED: an atlas of hotspots of viral proteins Zhang, HuiHui Chen, Pei Ma, Haojie Woińska, Magdalena Liu, Dejian Cooper, David R. Peng, Guo Peng, Yousong Deng, Lei Minor, Wladek Zheng, Heping IUCrJ Research Papers Metal binding sites, antigen epitopes and drug binding sites are the hotspots in viral proteins that control how viruses interact with their hosts. virusMED (virus Metal binding sites, Epitopes and Drug binding sites) is a rich internet application based on a database of atomic interactions around hotspots in 7041 experimentally determined viral protein structures. 25306 hotspots from 805 virus strains from 75 virus families were characterized, including influenza, HIV-1 and SARS-CoV-2 viruses. Just as Google Maps organizes and annotates points of interest, virusMED presents the positions of individual hotspots on each viral protein and creates an atlas upon which newly characterized functional sites can be placed as they are being discovered. virusMED contains an extensive set of annotation tags about the virus species and strains, viral hosts, viral proteins, metal ions, specific antibodies and FDA-approved drugs, which permits rapid screening of hotspots on viral proteins tailored to a particular research problem. The virusMED portal (https://virusmed.biocloud.top) can serve as a window to a valuable resource for many areas of virus research and play a critical role in the rational design of new preventative and therapeutic agents targeting viral infections. International Union of Crystallography 2021-09-28 /pmc/articles/PMC8479994/ /pubmed/34614039 http://dx.doi.org/10.1107/S2052252521009076 Text en © HuiHui Zhang et al. 2021 https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Research Papers
Zhang, HuiHui
Chen, Pei
Ma, Haojie
Woińska, Magdalena
Liu, Dejian
Cooper, David R.
Peng, Guo
Peng, Yousong
Deng, Lei
Minor, Wladek
Zheng, Heping
virusMED: an atlas of hotspots of viral proteins
title virusMED: an atlas of hotspots of viral proteins
title_full virusMED: an atlas of hotspots of viral proteins
title_fullStr virusMED: an atlas of hotspots of viral proteins
title_full_unstemmed virusMED: an atlas of hotspots of viral proteins
title_short virusMED: an atlas of hotspots of viral proteins
title_sort virusmed: an atlas of hotspots of viral proteins
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479994/
https://www.ncbi.nlm.nih.gov/pubmed/34614039
http://dx.doi.org/10.1107/S2052252521009076
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