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Combined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer

BACKGROUND: Smoking increases DNA methylation and DNA damage, and DNA damage acts as a vital cause of tumor development. The DNA methyltransferase 3B (DNMT3B) enhances promoter activity and methylation of tumor suppressor genes. Tea polyphenols may inhibit DNMT activity. We designed a case-control s...

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Detalles Bibliográficos
Autores principales:	Huang, Chia-Chen, Lai, Chung-Yu, Tsai, Chin-Hung, Wang, Jiun-Yao, Wong, Ruey-Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480053/ https://www.ncbi.nlm.nih.gov/pubmed/34587932 http://dx.doi.org/10.1186/s12885-021-08800-w

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