Minimal residual disease, long-term outcome, and IKZF1 deletions in children and adolescents with Down syndrome and acute lymphocytic leukaemia: a matched cohort study

BACKGROUND: Patients with Down syndrome and acute lymphocytic leukaemia are at an increased risk of treatment-related mortality and relapse, which is influenced by unfavourable genetic aberrations (eg, IKZF1 deletion). We aimed to investigate the potential underlying effect of Down syndrome versus t...

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Detalles Bibliográficos
Autores principales: Michels, Naomi, Boer, Judith M, Enshaei, Amir, Sutton, Rosemary, Heyman, Mats, Ebert, Sabine, Fiocco, Marta, de Groot-Kruseman, Hester A, van der Velden, Vincent H J, Barbany, Gisela, Escherich, Gabriele, Vora, Ajay, Trahair, Toby, Dalla-Pozza, Luciano, Pieters, Rob, zur Stadt, Udo, Schmiegelow, Kjeld, Moorman, Anthony V, Zwaan, C Michel, den Boer, Monique L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480280/
https://www.ncbi.nlm.nih.gov/pubmed/34560013
http://dx.doi.org/10.1016/S2352-3026(21)00272-6

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