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Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1

ADP-ribosylation is a pivotal post-translational modification that mediates various important cellular processes producing negatively charged biopolymer, poly (ADP-ribose), the functions of which need further elucidation. Toward this end, the availability of well-defined ADP-ribose (ADPr) oligomers...

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Detalles Bibliográficos
Autores principales:	Liu, Qiang, Knobloch, Gunnar, Voorneveld, Jim, Meeuwenoord, Nico J., Overkleeft, Herman S., van der Marel, Gijsbert A., Ladurner, Andreas G., Filippov, Dmitri V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480336/ https://www.ncbi.nlm.nih.gov/pubmed/34603678 http://dx.doi.org/10.1039/d1sc02340c

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