Encephalitis patient-derived monoclonal GABA(A) receptor antibodies cause epileptic seizures

Autoantibodies targeting the GABA(A) receptor (GABA(A)R) hallmark an autoimmune encephalitis presenting with frequent seizures and psychomotor abnormalities. Their pathogenic role is still not well-defined, given the common overlap with further autoantibodies and the lack of patient-derived mAbs. Fi...

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Detalles Bibliográficos
Autores principales: Kreye, Jakob, Wright, Sukhvir K., van Casteren, Adriana, Stöffler, Laura, Machule, Marie-Luise, Reincke, S. Momsen, Nikolaus, Marc, van Hoof, Scott, Sanchez-Sendin, Elisa, Homeyer, Marie A., Cordero Gómez, César, Kornau, Hans-Christian, Schmitz, Dietmar, Kaindl, Angela M., Boehm-Sturm, Philipp, Mueller, Susanne, Wilson, Max A., Upadhya, Manoj A., Dhangar, Divya R., Greenhill, Stuart, Woodhall, Gavin, Turko, Paul, Vida, Imre, Garner, Craig C., Wickel, Jonathan, Geis, Christian, Fukata, Yuko, Fukata, Masaki, Prüss, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480667/
https://www.ncbi.nlm.nih.gov/pubmed/34546336
http://dx.doi.org/10.1084/jem.20210012

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