Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C

Activating mutations in receptor guanylyl cyclase C (GC-C), the target of gastrointestinal peptide hormones guanylin and uroguanylin, and bacterial heat-stable enterotoxins cause early-onset diarrhea and chronic inflammatory bowel disease (IBD). GC-C regulates ion and fluid secretion in the gut via...

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Detalles Bibliográficos
Autores principales: Mishra, Vishwas, Bose, Avipsa, Kiran, Shashi, Banerjee, Sanghita, Shah, Idrees A., Chaukimath, Pooja, Reshi, Mudasir M., Srinivas, Swarna, Barman, Anaxee, Visweswariah, Sandhya S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480670/
https://www.ncbi.nlm.nih.gov/pubmed/34546338
http://dx.doi.org/10.1084/jem.20210479

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