BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

Activity of the NLRP3 inflammasome, a critical mediator of inflammation, is controlled by accessory proteins, posttranslational modifications, cellular localization, and oligomerization. How these factors relate is unclear. We show that a well-established drug target, Bruton’s tyrosine kinase (BTK),...

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Detalles Bibliográficos
Autores principales: Bittner, Zsófia Agnes, Liu, Xiao, Mateo Tortola, Maria, Tapia-Abellán, Ana, Shankar, Sangeetha, Andreeva, Liudmila, Mangan, Matthew, Spalinger, Marianne, Kalbacher, Hubert, Düwell, Peter, Lovotti, Marta, Bosch, Karlotta, Dickhöfer, Sabine, Marcu, Ana, Stevanović, Stefan, Herster, Franziska, Cardona Gloria, Yamel, Chang, Tzu-Hsuan, Bork, Francesca, Greve, Carsten L., Löffler, Markus W., Wolz, Olaf-Oliver, Schilling, Nadine A., Kümmerle-Deschner, Jasmin B., Wagner, Samuel, Delor, Anita, Grimbacher, Bodo, Hantschel, Oliver, Scharl, Michael, Wu, Hao, Latz, Eicke, Weber, Alexander N.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480672/
https://www.ncbi.nlm.nih.gov/pubmed/34554188
http://dx.doi.org/10.1084/jem.20201656

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