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Trends in urinary tract infection hospitalization in older adults in Spain from 2000-2015

OBJECTIVE: To analyze trends in urinary tract infection hospitalization (cystitis, pyelonephritis, prostatitis and non-specified UTI) among patients over 65 years in Spain from 2000–2015. METHODS: We conducted a retrospective observational study using the Spanish Hospitalization Minimum Data Set (CM...

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Autores principales: Redondo-Sánchez, Jesús, del Cura-González, Isabel, Díez-Izquierdo, Laura, Rodríguez-Barrientos, Ricardo, Rodríguez-Cabrera, Francisco, Polentinos-Castro, Elena, López-Miguel, Miguel, Marina-Ono, Lucas, Llamosas-Falcón, Laura, Gil-de Miguel, Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480842/
https://www.ncbi.nlm.nih.gov/pubmed/34587191
http://dx.doi.org/10.1371/journal.pone.0257546
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author Redondo-Sánchez, Jesús
del Cura-González, Isabel
Díez-Izquierdo, Laura
Rodríguez-Barrientos, Ricardo
Rodríguez-Cabrera, Francisco
Polentinos-Castro, Elena
López-Miguel, Miguel
Marina-Ono, Lucas
Llamosas-Falcón, Laura
Gil-de Miguel, Ángel
author_facet Redondo-Sánchez, Jesús
del Cura-González, Isabel
Díez-Izquierdo, Laura
Rodríguez-Barrientos, Ricardo
Rodríguez-Cabrera, Francisco
Polentinos-Castro, Elena
López-Miguel, Miguel
Marina-Ono, Lucas
Llamosas-Falcón, Laura
Gil-de Miguel, Ángel
author_sort Redondo-Sánchez, Jesús
collection PubMed
description OBJECTIVE: To analyze trends in urinary tract infection hospitalization (cystitis, pyelonephritis, prostatitis and non-specified UTI) among patients over 65 years in Spain from 2000–2015. METHODS: We conducted a retrospective observational study using the Spanish Hospitalization Minimum Data Set (CMBD), with codifications by the International Classification of Diseases (ICD-9). We collected data on sex, age, type of discharge, main diagnosis, comorbid diagnosis, length of stay, and global cost. All the hospitalizations were grouped by age into three categories: 65–74 years old, 75–84 years old, and 85 years old and above. In the descriptive statistical analysis, crude rates were defined as hospitalizations per 1,000 inhabitants aged ≥65. To identify trends over time, we performed a Joinpoint regression. RESULTS: From 2000–2015, we found 387,010 hospitalizations coded as UTIs (54,427 pyelonephritis, 15,869 prostatitis, 2643 cystitis and 314,071 non-specified UTI). The crude rate of hospitalization for UTIs between 2000 and 2015 ranged from 2.09 in 2000 to 4.33 in 2015 Rates of hospitalization were higher in men than in women, except with pyelonephritis. By age group, higher rates were observed in patients aged 85 years or older, barring prostatitis-related hospitalizations. Joinpoint analyses showed an average annual percentage increase (AAPC) in incidence rates of 4.9% (95% CI 3.2;6.1) in UTI hospitalizations. We observed two joinpoints, in 2010 and 2013, that found trends of 5.5% between 2000 and 2010 (95% CI 4.7;6.4), 1.5% between 2010 and 2013 (95% CI -6.0;9.6) and 6.8% between 2013 and 2015 (95% CI -0.3;14.4). CONCLUSIONS: The urinary infection-related hospitalization rate in Spain doubled during the period 2000–2015. The highest hospitalization rates occurred in men, in the ≥85 years old age group, and in non-specified UTIs. There were increases in all types of urinary tract infection, with non-specified UTIs having the greatest growth. Understanding these changing trends can be useful for health planning.
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spelling pubmed-84808422021-09-30 Trends in urinary tract infection hospitalization in older adults in Spain from 2000-2015 Redondo-Sánchez, Jesús del Cura-González, Isabel Díez-Izquierdo, Laura Rodríguez-Barrientos, Ricardo Rodríguez-Cabrera, Francisco Polentinos-Castro, Elena López-Miguel, Miguel Marina-Ono, Lucas Llamosas-Falcón, Laura Gil-de Miguel, Ángel PLoS One Research Article OBJECTIVE: To analyze trends in urinary tract infection hospitalization (cystitis, pyelonephritis, prostatitis and non-specified UTI) among patients over 65 years in Spain from 2000–2015. METHODS: We conducted a retrospective observational study using the Spanish Hospitalization Minimum Data Set (CMBD), with codifications by the International Classification of Diseases (ICD-9). We collected data on sex, age, type of discharge, main diagnosis, comorbid diagnosis, length of stay, and global cost. All the hospitalizations were grouped by age into three categories: 65–74 years old, 75–84 years old, and 85 years old and above. In the descriptive statistical analysis, crude rates were defined as hospitalizations per 1,000 inhabitants aged ≥65. To identify trends over time, we performed a Joinpoint regression. RESULTS: From 2000–2015, we found 387,010 hospitalizations coded as UTIs (54,427 pyelonephritis, 15,869 prostatitis, 2643 cystitis and 314,071 non-specified UTI). The crude rate of hospitalization for UTIs between 2000 and 2015 ranged from 2.09 in 2000 to 4.33 in 2015 Rates of hospitalization were higher in men than in women, except with pyelonephritis. By age group, higher rates were observed in patients aged 85 years or older, barring prostatitis-related hospitalizations. Joinpoint analyses showed an average annual percentage increase (AAPC) in incidence rates of 4.9% (95% CI 3.2;6.1) in UTI hospitalizations. We observed two joinpoints, in 2010 and 2013, that found trends of 5.5% between 2000 and 2010 (95% CI 4.7;6.4), 1.5% between 2010 and 2013 (95% CI -6.0;9.6) and 6.8% between 2013 and 2015 (95% CI -0.3;14.4). CONCLUSIONS: The urinary infection-related hospitalization rate in Spain doubled during the period 2000–2015. The highest hospitalization rates occurred in men, in the ≥85 years old age group, and in non-specified UTIs. There were increases in all types of urinary tract infection, with non-specified UTIs having the greatest growth. Understanding these changing trends can be useful for health planning. Public Library of Science 2021-09-29 /pmc/articles/PMC8480842/ /pubmed/34587191 http://dx.doi.org/10.1371/journal.pone.0257546 Text en © 2021 Redondo-Sánchez et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Redondo-Sánchez, Jesús
del Cura-González, Isabel
Díez-Izquierdo, Laura
Rodríguez-Barrientos, Ricardo
Rodríguez-Cabrera, Francisco
Polentinos-Castro, Elena
López-Miguel, Miguel
Marina-Ono, Lucas
Llamosas-Falcón, Laura
Gil-de Miguel, Ángel
Trends in urinary tract infection hospitalization in older adults in Spain from 2000-2015
title Trends in urinary tract infection hospitalization in older adults in Spain from 2000-2015
title_full Trends in urinary tract infection hospitalization in older adults in Spain from 2000-2015
title_fullStr Trends in urinary tract infection hospitalization in older adults in Spain from 2000-2015
title_full_unstemmed Trends in urinary tract infection hospitalization in older adults in Spain from 2000-2015
title_short Trends in urinary tract infection hospitalization in older adults in Spain from 2000-2015
title_sort trends in urinary tract infection hospitalization in older adults in spain from 2000-2015
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480842/
https://www.ncbi.nlm.nih.gov/pubmed/34587191
http://dx.doi.org/10.1371/journal.pone.0257546
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