Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome

Perturbation of the excitation/inhibition (E/I) balance leads to neurodevelopmental diseases including to autism spectrum disorders, intellectual disability, and epilepsy. Loss-of-function mutations in the DYRK1A gene, located on human chromosome 21 (Hsa21,) lead to an intellectual disability syndro...

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Detalles Bibliográficos
Autores principales: Brault, Véronique, Nguyen, Thu Lan, Flores-Gutiérrez, Javier, Iacono, Giovanni, Birling, Marie-Christine, Lalanne, Valérie, Meziane, Hamid, Manousopoulou, Antigoni, Pavlovic, Guillaume, Lindner, Loïc, Selloum, Mohammed, Sorg, Tania, Yu, Eugene, Garbis, Spiros D., Hérault, Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480849/
https://www.ncbi.nlm.nih.gov/pubmed/34587162
http://dx.doi.org/10.1371/journal.pgen.1009777

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