Cargando…

Leveraging publicly available coronavirus data to identify new therapeutic targets for COVID-19

Many important questions remain regarding severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the viral pathogen responsible for COVID-19. These questions include the mechanisms explaining the high percentage of asymptomatic but highly infectious individuals, the wide variability in diseas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sell, Stacy L., Prough, Donald S., Weisz, Harris A., Widen, Steve G., Hellmich, Helen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480897/ https://www.ncbi.nlm.nih.gov/pubmed/34587192 http://dx.doi.org/10.1371/journal.pone.0257965

Ejemplares similares

Principal component analysis of blood microRNA datasets facilitates diagnosis of diverse diseases
por: Sell, Stacy L., et al.
Publicado: (2020)

MicroRNA sequencing of rat hippocampus and human biofluids identifies acute, chronic, focal and diffuse traumatic brain injuries
por: Weisz, Harris A., et al.
Publicado: (2020)

MicroRNA profiling identifies a novel compound with antidepressant properties
por: Sell, Stacy L., et al.
Publicado: (2019)

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury
por: Weisz, Harris A., et al.
Publicado: (2017)

Mechanistic insights gained from cell and molecular analysis of the neuroprotective potential of bioactive natural compounds in an immortalized hippocampal cell line
por: Weisz, Harris A., et al.
Publicado: (2022)

Traumatic Brain Injury-Induced Dysregulation of the Circadian Clock
por: Boone, Deborah R., et al.
Publicado: (2012)

Pathway-Focused PCR Array Profiling of Enriched Populations of Laser Capture Microdissected Hippocampal Cells after Traumatic Brain Injury
por: Boone, Deborah R., et al.
Publicado: (2015)

Nano-Pulsed Laser Therapy Is Neuroprotective in a Rat Model of Blast-Induced Neurotrauma
por: Esenaliev, Rinat O., et al.
Publicado: (2018)

Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury
por: Hellmich, Helen L., et al.
Publicado: (2013)

Laser Capture Microdissection of Enriched Populations of Neurons or Single Neurons for Gene Expression Analysis After Traumatic Brain Injury
por: Boone, Deborah R., et al.
Publicado: (2013)

Effects of AAV-mediated knockdown of nNOS and GPx-1 gene expression in rat hippocampus after traumatic brain injury
por: Boone, Deborah R., et al.
Publicado: (2017)

In silico Analysis of Publicly Available Transcriptomics Data Identifies Putative Prognostic and Therapeutic Molecular Targets for Papillary Thyroid Carcinoma
por: Almansoori, Asma, et al.
Publicado: (2022)

Leveraging antimicrobial stewardship programs in response to the coronavirus disease 2019 (COVID-19) public health emergency
por: Joerger, Torsten A., et al.
Publicado: (2022)

Publisher Correction: Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury
por: Boone, Deborah Kennedy, et al.
Publicado: (2018)

Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury
por: Boone, Deborah Kennedy, et al.
Publicado: (2017)

Identifying Key Target Audiences for Public Health Campaigns: Leveraging Machine Learning in the Case of Hookah Tobacco Smoking
por: Chu, Kar-Hai, et al.
Publicado: (2019)

Meta-imputation of transcriptome from genotypes across multiple datasets by leveraging publicly available summary-level data
por: Liu, Andrew E., et al.
Publicado: (2022)

Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19
por: Fantini, Jacques, et al.
Publicado: (2021)

Traumatic brain injury induces long-lasting changes in immune and regenerative signaling
por: Boone, Deborah R., et al.
Publicado: (2019)

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets
por: Fu, Ci, et al.
Publicado: (2021)

An “Infodemic”: Leveraging High-Volume Twitter Data to Understand Early Public Sentiment for the Coronavirus Disease 2019 Outbreak
por: Medford, Richard J, et al.
Publicado: (2020)

Leveraging observational data to identify targeted patient populations for future randomized trials
por: Lazzareschi, Daniel V., et al.
Publicado: (2023)

2356: openSESAME: a “search engine” for discovering drug-disease connections by leveraging publicly available high-throughput experimental data
por: Gower, Adam C., et al.
Publicado: (2018)

EPEN-32. Leveraging cell surface targets as therapeutic vulnerabilities for pediatric ependymoma
por: Bertrand, Kelsey
Publicado: (2022)

Implications of publicly available genomic data resources in searching for therapeutic targets of obesity and type 2 diabetes
por: Jung, Sungwon
Publicado: (2018)

Identifying Differences in the Performance of Machine Learning Models for Off-Targets Trained on Publicly Available and Proprietary Data Sets
por: Smajić, Aljoša, et al.
Publicado: (2023)

The ALPHA Project: An architecture for leveraging public health applications
por: Turner, Cameron, et al.
Publicado: (2006)

Leveraging public data to offer online inquiry opportunities
por: Thompson, Seth K., et al.
Publicado: (2020)

Leveraging Citizen Science to Improve Urban Public Health
por: Hotting, J, et al.
Publicado: (2022)

THU119 Screening Publicly Available Data To Identify Candidate Genes For Congenital Hypopituitarism
por: Brinkmeier, Michelle L, et al.
Publicado: (2023)

A Taxonomy-Agnostic Approach to Targeted Microbiome Therapeutics—Leveraging Principles of Systems Biology
por: Brumfield, Kyle D., et al.
Publicado: (2023)

The Quest for Signals in Noise: Leveraging Experiential Variation to Identify Bilingual Phenotypes
por: Beatty-Martínez, Anne L., et al.
Publicado: (2021)

PIN50 Leveraging Publicly Available Data to Estimate a Real-Time Reproduction Number (Rt) for Covid-19: A Comparison of Two Methods
por: Emerson, S., et al.
Publicado: (2021)

Effectively utilizing publicly available databases for cancer target evaluation
por: Croft, Daniel, et al.
Publicado: (2023)

JBoss EAP6 high availability: leverage the power of JBoss EAP6 to successfully build high-availability clusters quickly and efficiently
por: Li, Weinan
Publicado: (2013)

Traceback: leveraging archived biospecimens to identify mutation carriers
por: Samimi, Goli, et al.
Publicado: (2017)

The Gene Expression Barcode: leveraging public data repositories to begin cataloging the human and murine transcriptomes
por: McCall, Matthew N., et al.
Publicado: (2011)

Leveraging Available Resources and Stakeholder Involvement for Improved Productivity of African Livestock in the Era of Genomic Breeding
por: Ibeagha-Awemu, Eveline M., et al.
Publicado: (2019)

Leveraging Visual Place Recognition to Improve Indoor Positioning with Limited Availability of WiFi Scans
por: Nowicki, Michał R., et al.
Publicado: (2019)

Leveraging MYC as a therapeutic treatment option for TNBC
por: Carey, Jason P.W., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6f9lvioghndemp6pv9j9mhvaq9