G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy

Mutant isocitrate-dehydrogenase 1 (mIDH1) synthesizes the oncometabolite 2-hydroxyglutarate (2HG), which elicits epigenetic reprogramming of the glioma cells’ transcriptome by inhibiting DNA and histone demethylases. We show that the efficacy of immune-stimulatory gene therapy (TK/Flt3L) is enhanced...

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Detalles Bibliográficos
Autores principales: Alghamri, Mahmoud S., McClellan, Brandon L., Avvari, Ruthvik P., Thalla, Rohit, Carney, Stephen, Hartlage, Margaret S., Haase, Santiago, Ventosa, Maria, Taher, Ayman, Kamran, Neha, Zhang, Li, Faisal, Syed Mohd, Núñez, Felipe J., Garcia-Fabiani, María Belén, Al-Holou, Wajd N., Orringer, Daniel, Hervey-Jumper, Shawn, Heth, Jason, Patil, Parag G., Eddy, Karen, Merajver, Sofia D., Ulintz, Peter J., Welch, Joshua, Gao, Chao, Liu, Jialin, Núñez, Gabriel, Hambardzumyan, Dolores, Lowenstein, Pedro R., Castro, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480930/
https://www.ncbi.nlm.nih.gov/pubmed/34586841
http://dx.doi.org/10.1126/sciadv.abh3243

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