Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity

Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA (cDNA) has been implicated in retinal pigmented epithelium (RPE) degeneration. The mechanism of Alu cDNA–induced cytotoxicity and its relevance to human disease are unknown....

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Detalles Bibliográficos
Autores principales: Fukuda, Shinichi, Narendran, Siddharth, Varshney, Akhil, Nagasaka, Yosuke, Wang, Shao-bin, Ambati, Kameshwari, Apicella, Ivana, Pereira, Felipe, Fowler, Benjamin J., Yasuma, Tetsuhiro, Hirahara, Shuichiro, Yasuma, Reo, Huang, Peirong, Yerramothu, Praveen, Makin, Ryan D., Wang, Mo, Baker, Kirstie L., Marion, Kenneth M., Huang, Xiwen, Baghdasaryan, Elmira, Ambati, Meenakshi, Ambati, Vidya L., Banerjee, Daipayan, Bonilha, Vera L., Tolstonog, Genrich V., Held, Ulrike, Ogura, Yuichiro, Terasaki, Hiroko, Oshika, Tetsuro, Bhattarai, Deepak, Kim, Kyung Bo, Feldman, Sanford H., Aguirre, J. Ignacio, Hinton, David R., Kerur, Nagaraj, Sadda, Srinivas R., Schumann, Gerald G., Gelfand, Bradley D., Ambati, Jayakrishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480932/
https://www.ncbi.nlm.nih.gov/pubmed/34586848
http://dx.doi.org/10.1126/sciadv.abj3658

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