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Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics

How do cells perceive time? Do cells use temporal information to regulate the production/degradation of their enzymes, membranes, and organelles? Does controlling biological time influence cytoskeletal organization and cellular architecture in ways that confer evolutionary and physiological advantag...

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Autores principales: Mofatteh, Mohammad, Echegaray-Iturra, Fabio, Alamban, Andrew, Dalla Ricca, Francesco, Bakshi, Anand, Aydogan, Mustafa G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480978/
https://www.ncbi.nlm.nih.gov/pubmed/34586070
http://dx.doi.org/10.7554/eLife.72104
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author Mofatteh, Mohammad
Echegaray-Iturra, Fabio
Alamban, Andrew
Dalla Ricca, Francesco
Bakshi, Anand
Aydogan, Mustafa G
author_facet Mofatteh, Mohammad
Echegaray-Iturra, Fabio
Alamban, Andrew
Dalla Ricca, Francesco
Bakshi, Anand
Aydogan, Mustafa G
author_sort Mofatteh, Mohammad
collection PubMed
description How do cells perceive time? Do cells use temporal information to regulate the production/degradation of their enzymes, membranes, and organelles? Does controlling biological time influence cytoskeletal organization and cellular architecture in ways that confer evolutionary and physiological advantages? Potential answers to these fundamental questions of cell biology have historically revolved around the discussion of ‘master’ temporal programs, such as the principal cyclin-dependent kinase/cyclin cell division oscillator and the circadian clock. In this review, we provide an overview of the recent evidence supporting an emerging concept of ‘autonomous clocks,’ which under normal conditions can be entrained by the cell cycle and/or the circadian clock to run at their pace, but can also run independently to serve their functions if/when these major temporal programs are halted/abrupted. We begin the discussion by introducing recent developments in the study of such clocks and their roles at different scales and complexities. We then use current advances to elucidate the logic and molecular architecture of temporal networks that comprise autonomous clocks, providing important clues as to how these clocks may have evolved to run independently and, sometimes at the cost of redundancy, have strongly coupled to run under the full command of the cell cycle and/or the circadian clock. Next, we review a list of important recent findings that have shed new light onto potential hallmarks of autonomous clocks, suggestive of prospective theoretical and experimental approaches to further accelerate their discovery. Finally, we discuss their roles in health and disease, as well as possible therapeutic opportunities that targeting the autonomous clocks may offer.
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spelling pubmed-84809782021-09-30 Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics Mofatteh, Mohammad Echegaray-Iturra, Fabio Alamban, Andrew Dalla Ricca, Francesco Bakshi, Anand Aydogan, Mustafa G eLife Cell Biology How do cells perceive time? Do cells use temporal information to regulate the production/degradation of their enzymes, membranes, and organelles? Does controlling biological time influence cytoskeletal organization and cellular architecture in ways that confer evolutionary and physiological advantages? Potential answers to these fundamental questions of cell biology have historically revolved around the discussion of ‘master’ temporal programs, such as the principal cyclin-dependent kinase/cyclin cell division oscillator and the circadian clock. In this review, we provide an overview of the recent evidence supporting an emerging concept of ‘autonomous clocks,’ which under normal conditions can be entrained by the cell cycle and/or the circadian clock to run at their pace, but can also run independently to serve their functions if/when these major temporal programs are halted/abrupted. We begin the discussion by introducing recent developments in the study of such clocks and their roles at different scales and complexities. We then use current advances to elucidate the logic and molecular architecture of temporal networks that comprise autonomous clocks, providing important clues as to how these clocks may have evolved to run independently and, sometimes at the cost of redundancy, have strongly coupled to run under the full command of the cell cycle and/or the circadian clock. Next, we review a list of important recent findings that have shed new light onto potential hallmarks of autonomous clocks, suggestive of prospective theoretical and experimental approaches to further accelerate their discovery. Finally, we discuss their roles in health and disease, as well as possible therapeutic opportunities that targeting the autonomous clocks may offer. eLife Sciences Publications, Ltd 2021-09-29 /pmc/articles/PMC8480978/ /pubmed/34586070 http://dx.doi.org/10.7554/eLife.72104 Text en © 2021, Mofatteh et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cell Biology
Mofatteh, Mohammad
Echegaray-Iturra, Fabio
Alamban, Andrew
Dalla Ricca, Francesco
Bakshi, Anand
Aydogan, Mustafa G
Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics
title Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics
title_full Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics
title_fullStr Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics
title_full_unstemmed Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics
title_short Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics
title_sort autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480978/
https://www.ncbi.nlm.nih.gov/pubmed/34586070
http://dx.doi.org/10.7554/eLife.72104
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