Induction Chemotherapy for Orbit Preservation in Sinonasal Squamous Cell Carcinoma

Sinonasal squamous cell carcinoma (SNSCC) is a rare and aggressive malignancy which often presents at an advanced stage. The gold-standard treatment includes negative-margin surgical resection plus adjuvant therapy. In cases of orbital invasion, surgery requires orbital exenteration which can carry...

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Autores principales: Lilly, Gabriela, Geltzeiler, Mathew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481003/
https://www.ncbi.nlm.nih.gov/pubmed/34603932
http://dx.doi.org/10.1055/s-0041-1736160
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author Lilly, Gabriela
Geltzeiler, Mathew
author_facet Lilly, Gabriela
Geltzeiler, Mathew
author_sort Lilly, Gabriela
collection PubMed
description Sinonasal squamous cell carcinoma (SNSCC) is a rare and aggressive malignancy which often presents at an advanced stage. The gold-standard treatment includes negative-margin surgical resection plus adjuvant therapy. In cases of orbital invasion, surgery requires orbital exenteration which can carry significant morbidity and result in decreased quality of life. In selected patients, induction chemotherapy (IC) can allow for orbit preservation without compromising oncologic outcomes. The available literature will be briefly discussed.
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spelling pubmed-84810032021-10-01 Induction Chemotherapy for Orbit Preservation in Sinonasal Squamous Cell Carcinoma Lilly, Gabriela Geltzeiler, Mathew J Neurol Surg Rep Sinonasal squamous cell carcinoma (SNSCC) is a rare and aggressive malignancy which often presents at an advanced stage. The gold-standard treatment includes negative-margin surgical resection plus adjuvant therapy. In cases of orbital invasion, surgery requires orbital exenteration which can carry significant morbidity and result in decreased quality of life. In selected patients, induction chemotherapy (IC) can allow for orbit preservation without compromising oncologic outcomes. The available literature will be briefly discussed. Georg Thieme Verlag KG 2021-09-29 /pmc/articles/PMC8481003/ /pubmed/34603932 http://dx.doi.org/10.1055/s-0041-1736160 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Lilly, Gabriela
Geltzeiler, Mathew
Induction Chemotherapy for Orbit Preservation in Sinonasal Squamous Cell Carcinoma
title Induction Chemotherapy for Orbit Preservation in Sinonasal Squamous Cell Carcinoma
title_full Induction Chemotherapy for Orbit Preservation in Sinonasal Squamous Cell Carcinoma
title_fullStr Induction Chemotherapy for Orbit Preservation in Sinonasal Squamous Cell Carcinoma
title_full_unstemmed Induction Chemotherapy for Orbit Preservation in Sinonasal Squamous Cell Carcinoma
title_short Induction Chemotherapy for Orbit Preservation in Sinonasal Squamous Cell Carcinoma
title_sort induction chemotherapy for orbit preservation in sinonasal squamous cell carcinoma
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481003/
https://www.ncbi.nlm.nih.gov/pubmed/34603932
http://dx.doi.org/10.1055/s-0041-1736160
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