A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient

We report a case of a heart transplant recipient who presented with a rapidly growing Epstein-Barr virus (EBV)–positive, diffuse large B-cell lymphoma 7 days after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. Because of the atypical radiologic presentation, the initial tentative diagnosi...

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Autores principales: Tang, Wen-Ruei, Hsu, Che-Wei, Lee, Chia-Chi, Huang, Wei-Li, Lin, Chia-Ying, Hsu, Ya-Ting, Chang, Chen, Tsai, Meng-Ta, Hu, Yu-Ning, Hsu, Chih-Hsin, Chen, Po-Lin, Chow, Nan-Haw, Roan, Jun-Neng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481090/
https://www.ncbi.nlm.nih.gov/pubmed/34702598
http://dx.doi.org/10.1016/j.transproceed.2021.09.006
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author Tang, Wen-Ruei
Hsu, Che-Wei
Lee, Chia-Chi
Huang, Wei-Li
Lin, Chia-Ying
Hsu, Ya-Ting
Chang, Chen
Tsai, Meng-Ta
Hu, Yu-Ning
Hsu, Chih-Hsin
Chen, Po-Lin
Chow, Nan-Haw
Roan, Jun-Neng
author_facet Tang, Wen-Ruei
Hsu, Che-Wei
Lee, Chia-Chi
Huang, Wei-Li
Lin, Chia-Ying
Hsu, Ya-Ting
Chang, Chen
Tsai, Meng-Ta
Hu, Yu-Ning
Hsu, Chih-Hsin
Chen, Po-Lin
Chow, Nan-Haw
Roan, Jun-Neng
author_sort Tang, Wen-Ruei
collection PubMed
description We report a case of a heart transplant recipient who presented with a rapidly growing Epstein-Barr virus (EBV)–positive, diffuse large B-cell lymphoma 7 days after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. Because of the atypical radiologic presentation, the initial tentative diagnosis was a mediastinal abscess. This observation indicates a potential risk of EBV reactivation after coronavirus disease 2019 (COVID-19) vaccination, which might lead to or aggravate the presentation of posttransplant lymphoproliferative disorder in transplantation patients. Transplant surgeons should be aware of the potential immunomodulatory effects of the COVID-19 vaccination.
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spelling pubmed-84810902021-09-30 A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient Tang, Wen-Ruei Hsu, Che-Wei Lee, Chia-Chi Huang, Wei-Li Lin, Chia-Ying Hsu, Ya-Ting Chang, Chen Tsai, Meng-Ta Hu, Yu-Ning Hsu, Chih-Hsin Chen, Po-Lin Chow, Nan-Haw Roan, Jun-Neng Transplant Proc Article We report a case of a heart transplant recipient who presented with a rapidly growing Epstein-Barr virus (EBV)–positive, diffuse large B-cell lymphoma 7 days after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. Because of the atypical radiologic presentation, the initial tentative diagnosis was a mediastinal abscess. This observation indicates a potential risk of EBV reactivation after coronavirus disease 2019 (COVID-19) vaccination, which might lead to or aggravate the presentation of posttransplant lymphoproliferative disorder in transplantation patients. Transplant surgeons should be aware of the potential immunomodulatory effects of the COVID-19 vaccination. Elsevier Inc. 2022 2021-09-30 /pmc/articles/PMC8481090/ /pubmed/34702598 http://dx.doi.org/10.1016/j.transproceed.2021.09.006 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tang, Wen-Ruei
Hsu, Che-Wei
Lee, Chia-Chi
Huang, Wei-Li
Lin, Chia-Ying
Hsu, Ya-Ting
Chang, Chen
Tsai, Meng-Ta
Hu, Yu-Ning
Hsu, Chih-Hsin
Chen, Po-Lin
Chow, Nan-Haw
Roan, Jun-Neng
A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient
title A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient
title_full A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient
title_fullStr A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient
title_full_unstemmed A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient
title_short A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient
title_sort case report of posttransplant lymphoproliferative disorder after astrazeneca coronavirus disease 2019 vaccine in a heart transplant recipient
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481090/
https://www.ncbi.nlm.nih.gov/pubmed/34702598
http://dx.doi.org/10.1016/j.transproceed.2021.09.006
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