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The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression

Nonstructural protein 1 (nsp1) is a coronavirus (CoV) virulence factor that restricts cellular gene expression by inhibiting translation through blocking the mRNA entry channel of the 40S ribosomal subunit and by promoting mRNA degradation. We perform a detailed structure-guided mutational analysis...

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Detalles Bibliográficos
Autores principales:	Mendez, Aaron S., Ly, Michael, González-Sánchez, Angélica M., Hartenian, Ella, Ingolia, Nicholas T., Cate, Jamie H., Glaunsinger, Britt A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Authors. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481097/ https://www.ncbi.nlm.nih.gov/pubmed/34624207 http://dx.doi.org/10.1016/j.celrep.2021.109841

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