CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum

Regulation of chromatin plays fundamental roles in the development of the brain. Haploinsufficiency of the chromatin remodeling enzyme CHD7 causes CHARGE syndrome, a genetic disorder that affects the development of the cerebellum. However, how CHD7 controls chromatin states in the cerebellum remains...

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Detalles Bibliográficos
Autores principales: Reddy, Naveen C., Majidi, Shahriyar P., Kong, Lingchun, Nemera, Mati, Ferguson, Cole J., Moore, Michael, Goncalves, Tassia M., Liu, Hai-Kun, Fitzpatrick, James A. J., Zhao, Guoyan, Yamada, Tomoko, Bonni, Azad, Gabel, Harrison W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481233/
https://www.ncbi.nlm.nih.gov/pubmed/34588434
http://dx.doi.org/10.1038/s41467-021-25846-3

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