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Refractive lens power and lens thickness in children (6–16 years old)
To examine the refractive lens power (RLP) and lens thickness and their associated factors in children from North-Western China. Children from two schools (primary school and junior high school) in the North-Western Chinese province of Qinghai underwent a comprehensive ophthalmic examination includi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481242/ https://www.ncbi.nlm.nih.gov/pubmed/34588558 http://dx.doi.org/10.1038/s41598-021-98817-9 |
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author | Lu, Tailiang Song, Jike Wu, Qiuxin Jiang, Wenjun Tian, Qingmei Zhang, Xiuyan Xu, Jing Wu, Jianfeng Hu, Yuanyuan Sun, Wei Bi, Hongsheng |
author_facet | Lu, Tailiang Song, Jike Wu, Qiuxin Jiang, Wenjun Tian, Qingmei Zhang, Xiuyan Xu, Jing Wu, Jianfeng Hu, Yuanyuan Sun, Wei Bi, Hongsheng |
author_sort | Lu, Tailiang |
collection | PubMed |
description | To examine the refractive lens power (RLP) and lens thickness and their associated factors in children from North-Western China. Children from two schools (primary school and junior high school) in the North-Western Chinese province of Qinghai underwent a comprehensive ophthalmic examination including biometry and cycloplegic refractometry. The RLP was calculated using Bennett’s equation. The study included 596 (77.9%) individuals (mean age: 11.0 ± 2.8 years; range: 6–16 years) with a mean axial length of 23.65 ± 1.24 mm (range: 20.02–27.96 mm). Mean lens thickness was 3.30 ± 0.16 mm (range: 2.85–3.99 mm) and mean RLP was 24.85 ± 1.98D (range: 19.40–32.97). In univariate analysis, girls as compared to boys had a significantly thicker lens and greater RLP, shorter axial length, smaller corneal curvature radius and shorter corneal curvature radius (all P < 0.001). Both sexes did not differ significantly in refractive error (P = 0.11) and corneal thickness (P = 0.16). RLP was positively associated with refractive error (correlation coefficient r = 0.33; P < 0.001) and lens thickness (r = 0.62; P < 0.001) and negatively with axial length (r = − 0.70; P < 0.001). In univariate analysis, RLP decreased significantly with older age in the age group from age 6–13, while it plateaued thereafter, with no significant difference between boys and girls. In multivariate regression analysis, a higher RLP was associated with younger age (P < 0.001; standard regression coefficient β = − 0.07), female sex (P < 0.001; β = − 0.08), shorter axial length (P < 0.001; β = − 0.48) and higher lens thickness (P < 0.001; β = 0.42). In Chinese children, RLP with a mean of 24.85 ± 1.98D decreases with older age, male sex, longer axial length, and thinner lens thickness. Changes in RLP and axial length elongation are important players in the emmetropization and myopization. |
format | Online Article Text |
id | pubmed-8481242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84812422021-09-30 Refractive lens power and lens thickness in children (6–16 years old) Lu, Tailiang Song, Jike Wu, Qiuxin Jiang, Wenjun Tian, Qingmei Zhang, Xiuyan Xu, Jing Wu, Jianfeng Hu, Yuanyuan Sun, Wei Bi, Hongsheng Sci Rep Article To examine the refractive lens power (RLP) and lens thickness and their associated factors in children from North-Western China. Children from two schools (primary school and junior high school) in the North-Western Chinese province of Qinghai underwent a comprehensive ophthalmic examination including biometry and cycloplegic refractometry. The RLP was calculated using Bennett’s equation. The study included 596 (77.9%) individuals (mean age: 11.0 ± 2.8 years; range: 6–16 years) with a mean axial length of 23.65 ± 1.24 mm (range: 20.02–27.96 mm). Mean lens thickness was 3.30 ± 0.16 mm (range: 2.85–3.99 mm) and mean RLP was 24.85 ± 1.98D (range: 19.40–32.97). In univariate analysis, girls as compared to boys had a significantly thicker lens and greater RLP, shorter axial length, smaller corneal curvature radius and shorter corneal curvature radius (all P < 0.001). Both sexes did not differ significantly in refractive error (P = 0.11) and corneal thickness (P = 0.16). RLP was positively associated with refractive error (correlation coefficient r = 0.33; P < 0.001) and lens thickness (r = 0.62; P < 0.001) and negatively with axial length (r = − 0.70; P < 0.001). In univariate analysis, RLP decreased significantly with older age in the age group from age 6–13, while it plateaued thereafter, with no significant difference between boys and girls. In multivariate regression analysis, a higher RLP was associated with younger age (P < 0.001; standard regression coefficient β = − 0.07), female sex (P < 0.001; β = − 0.08), shorter axial length (P < 0.001; β = − 0.48) and higher lens thickness (P < 0.001; β = 0.42). In Chinese children, RLP with a mean of 24.85 ± 1.98D decreases with older age, male sex, longer axial length, and thinner lens thickness. Changes in RLP and axial length elongation are important players in the emmetropization and myopization. Nature Publishing Group UK 2021-09-29 /pmc/articles/PMC8481242/ /pubmed/34588558 http://dx.doi.org/10.1038/s41598-021-98817-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lu, Tailiang Song, Jike Wu, Qiuxin Jiang, Wenjun Tian, Qingmei Zhang, Xiuyan Xu, Jing Wu, Jianfeng Hu, Yuanyuan Sun, Wei Bi, Hongsheng Refractive lens power and lens thickness in children (6–16 years old) |
title | Refractive lens power and lens thickness in children (6–16 years old) |
title_full | Refractive lens power and lens thickness in children (6–16 years old) |
title_fullStr | Refractive lens power and lens thickness in children (6–16 years old) |
title_full_unstemmed | Refractive lens power and lens thickness in children (6–16 years old) |
title_short | Refractive lens power and lens thickness in children (6–16 years old) |
title_sort | refractive lens power and lens thickness in children (6–16 years old) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481242/ https://www.ncbi.nlm.nih.gov/pubmed/34588558 http://dx.doi.org/10.1038/s41598-021-98817-9 |
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