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Retinal vessels modifications in acute and post-COVID-19

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2 primarily affecting the respiratory system which can damage vessels walls virtually in any body district. Changes affecting retinal vessels are a good marker for systemic vascular alterations. This study investigated r...

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Autores principales: Invernizzi, Alessandro, Schiuma, Marco, Parrulli, Salvatore, Torre, Alessandro, Zicarelli, Federico, Colombo, Valeria, Marini, Sara, Villella, Elena, Bertoni, Alice, Antinori, Spinello, Rizzardini, Giuliano, Galli, Massimo, Meroni, Luca, Giacomelli, Andrea, Staurenghi, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481283/
https://www.ncbi.nlm.nih.gov/pubmed/34588541
http://dx.doi.org/10.1038/s41598-021-98873-1
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author Invernizzi, Alessandro
Schiuma, Marco
Parrulli, Salvatore
Torre, Alessandro
Zicarelli, Federico
Colombo, Valeria
Marini, Sara
Villella, Elena
Bertoni, Alice
Antinori, Spinello
Rizzardini, Giuliano
Galli, Massimo
Meroni, Luca
Giacomelli, Andrea
Staurenghi, Giovanni
author_facet Invernizzi, Alessandro
Schiuma, Marco
Parrulli, Salvatore
Torre, Alessandro
Zicarelli, Federico
Colombo, Valeria
Marini, Sara
Villella, Elena
Bertoni, Alice
Antinori, Spinello
Rizzardini, Giuliano
Galli, Massimo
Meroni, Luca
Giacomelli, Andrea
Staurenghi, Giovanni
author_sort Invernizzi, Alessandro
collection PubMed
description Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2 primarily affecting the respiratory system which can damage vessels walls virtually in any body district. Changes affecting retinal vessels are a good marker for systemic vascular alterations. This study investigated retinal vessels during the acute phase of COVID-19 and after patients recovery. Fifty-nine eyes from 32 COVID-19 patients and 80 eyes from 53 unexposed subjects were included. Mean arteries diameter (MAD) and mean veins diameter (MVD) were assessed through semi-automatic analysis on fundus color photos at baseline and 6 months later in patients and subjects unexposed to the virus. At baseline MAD and MVD were significantly higher in COVID-19 patients compared to unexposed subjects (p < 0.0001). Both MAD and MVD significantly decreased in COVID-19 patients at follow-up (from 97.5 ± 10.9 to 92.2 ± 11.4 µm, p < 0.0001 and from 133.1 ± 19.3 to 124.6 ± 16.1 µm, p < 0.0001, respectively). Despite this reduction vessels diameter remained significantly higher in severe COVID-19 patients compared to unexposed subjects. Transient retinal vessels dilation could serve a biomarker for systemic inflammation while long-lasting alterations seen in severe COVID-19 likely reflect irreversible structural damage to the vessels walls and should be further investigated for their possible effects on tissues perfusion and function.
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spelling pubmed-84812832021-09-30 Retinal vessels modifications in acute and post-COVID-19 Invernizzi, Alessandro Schiuma, Marco Parrulli, Salvatore Torre, Alessandro Zicarelli, Federico Colombo, Valeria Marini, Sara Villella, Elena Bertoni, Alice Antinori, Spinello Rizzardini, Giuliano Galli, Massimo Meroni, Luca Giacomelli, Andrea Staurenghi, Giovanni Sci Rep Article Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2 primarily affecting the respiratory system which can damage vessels walls virtually in any body district. Changes affecting retinal vessels are a good marker for systemic vascular alterations. This study investigated retinal vessels during the acute phase of COVID-19 and after patients recovery. Fifty-nine eyes from 32 COVID-19 patients and 80 eyes from 53 unexposed subjects were included. Mean arteries diameter (MAD) and mean veins diameter (MVD) were assessed through semi-automatic analysis on fundus color photos at baseline and 6 months later in patients and subjects unexposed to the virus. At baseline MAD and MVD were significantly higher in COVID-19 patients compared to unexposed subjects (p < 0.0001). Both MAD and MVD significantly decreased in COVID-19 patients at follow-up (from 97.5 ± 10.9 to 92.2 ± 11.4 µm, p < 0.0001 and from 133.1 ± 19.3 to 124.6 ± 16.1 µm, p < 0.0001, respectively). Despite this reduction vessels diameter remained significantly higher in severe COVID-19 patients compared to unexposed subjects. Transient retinal vessels dilation could serve a biomarker for systemic inflammation while long-lasting alterations seen in severe COVID-19 likely reflect irreversible structural damage to the vessels walls and should be further investigated for their possible effects on tissues perfusion and function. Nature Publishing Group UK 2021-09-29 /pmc/articles/PMC8481283/ /pubmed/34588541 http://dx.doi.org/10.1038/s41598-021-98873-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Invernizzi, Alessandro
Schiuma, Marco
Parrulli, Salvatore
Torre, Alessandro
Zicarelli, Federico
Colombo, Valeria
Marini, Sara
Villella, Elena
Bertoni, Alice
Antinori, Spinello
Rizzardini, Giuliano
Galli, Massimo
Meroni, Luca
Giacomelli, Andrea
Staurenghi, Giovanni
Retinal vessels modifications in acute and post-COVID-19
title Retinal vessels modifications in acute and post-COVID-19
title_full Retinal vessels modifications in acute and post-COVID-19
title_fullStr Retinal vessels modifications in acute and post-COVID-19
title_full_unstemmed Retinal vessels modifications in acute and post-COVID-19
title_short Retinal vessels modifications in acute and post-COVID-19
title_sort retinal vessels modifications in acute and post-covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481283/
https://www.ncbi.nlm.nih.gov/pubmed/34588541
http://dx.doi.org/10.1038/s41598-021-98873-1
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