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IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming

To understand the role of polyploid giant cancer cells (PGCCs) in drug resistance and disease relapse, we examined the mRNA expression profile of PGCCs following treatment with paclitaxel in ovarian cancer cells. An acute activation of IL-6 dominated senescence-associated secretory phenotype lasted...

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Detalles Bibliográficos
Autores principales:	Niu, Na, Yao, Jun, Bast, Robert C., Sood, Anil K., Liu, Jinsong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481288/ https://www.ncbi.nlm.nih.gov/pubmed/34588424 http://dx.doi.org/10.1038/s41389-021-00349-4

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