Structural basis for UFM1 transfer from UBA5 to UFC1

Ufmylation is a post-translational modification essential for regulating key cellular processes. A three-enzyme cascade involving E1, E2 and E3 is required for UFM1 attachment to target proteins. How UBA5 (E1) and UFC1 (E2) cooperatively activate and transfer UFM1 is still unclear. Here, we present...

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Detalles Bibliográficos
Autores principales: Kumar, Manoj, Padala, Prasanth, Fahoum, Jamal, Hassouna, Fouad, Tsaban, Tomer, Zoltsman, Guy, Banerjee, Sayanika, Cohen-Kfir, Einav, Dessau, Moshe, Rosenzweig, Rina, Isupov, Michail N., Schueler-Furman, Ora, Wiener, Reuven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481289/
https://www.ncbi.nlm.nih.gov/pubmed/34588452
http://dx.doi.org/10.1038/s41467-021-25994-6

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