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Doublecortin-Expressing Neurons in Chinese Tree Shrew Forebrain Exhibit Mixed Rodent and Primate-Like Topographic Characteristics

Doublecortin (DCX) is transiently expressed in new-born neurons in the subventricular zone (SVZ) and subgranular zone (SGZ) related to adult neurogenesis in the olfactory bulb (OB) and hippocampal formation. DCX immunoreactive (DCX+) immature neurons also occur in the cerebral cortex primarily over...

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Autores principales: Ai, Jia-Qi, Luo, Rongcan, Tu, Tian, Yang, Chen, Jiang, Juan, Zhang, Bo, Bi, Rui, Tu, Ewen, Yao, Yong-Gang, Yan, Xiao-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481370/
https://www.ncbi.nlm.nih.gov/pubmed/34602987
http://dx.doi.org/10.3389/fnana.2021.727883
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author Ai, Jia-Qi
Luo, Rongcan
Tu, Tian
Yang, Chen
Jiang, Juan
Zhang, Bo
Bi, Rui
Tu, Ewen
Yao, Yong-Gang
Yan, Xiao-Xin
author_facet Ai, Jia-Qi
Luo, Rongcan
Tu, Tian
Yang, Chen
Jiang, Juan
Zhang, Bo
Bi, Rui
Tu, Ewen
Yao, Yong-Gang
Yan, Xiao-Xin
author_sort Ai, Jia-Qi
collection PubMed
description Doublecortin (DCX) is transiently expressed in new-born neurons in the subventricular zone (SVZ) and subgranular zone (SGZ) related to adult neurogenesis in the olfactory bulb (OB) and hippocampal formation. DCX immunoreactive (DCX+) immature neurons also occur in the cerebral cortex primarily over layer II and the amygdala around the paralaminar nucleus (PLN) in various mammals, with interspecies differences pointing to phylogenic variation. The tree shrews (Tupaia belangeri) are phylogenetically closer to primates than to rodents. Little is known about DCX+ neurons in the brain of this species. In the present study, we characterized DCX immunoreactivity (IR) in the forebrain of Chinese tree shrews aged from 2 months- to 6 years-old (n = 18). DCX+ cells were present in the OB, SVZ, SGZ, the piriform cortex over layer II, and the amygdala around the PLN. The numerical densities of DCX+ neurons were reduced in all above neuroanatomical regions with age, particularly dramatic in the DG in the 5–6 years-old animals. Thus, DCX+ neurons are present in the two established neurogenic sites (SVZ and SGZ) in the Chinese tree shrew as seen in other mammals. DCX+ cortical neurons in this animal exhibit a topographic pattern comparable to that in mice and rats, while these immature neurons are also present in the amygdala, concentrating around the PLN as seen in primates and some nonprimate mammals.
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spelling pubmed-84813702021-10-01 Doublecortin-Expressing Neurons in Chinese Tree Shrew Forebrain Exhibit Mixed Rodent and Primate-Like Topographic Characteristics Ai, Jia-Qi Luo, Rongcan Tu, Tian Yang, Chen Jiang, Juan Zhang, Bo Bi, Rui Tu, Ewen Yao, Yong-Gang Yan, Xiao-Xin Front Neuroanat Neuroscience Doublecortin (DCX) is transiently expressed in new-born neurons in the subventricular zone (SVZ) and subgranular zone (SGZ) related to adult neurogenesis in the olfactory bulb (OB) and hippocampal formation. DCX immunoreactive (DCX+) immature neurons also occur in the cerebral cortex primarily over layer II and the amygdala around the paralaminar nucleus (PLN) in various mammals, with interspecies differences pointing to phylogenic variation. The tree shrews (Tupaia belangeri) are phylogenetically closer to primates than to rodents. Little is known about DCX+ neurons in the brain of this species. In the present study, we characterized DCX immunoreactivity (IR) in the forebrain of Chinese tree shrews aged from 2 months- to 6 years-old (n = 18). DCX+ cells were present in the OB, SVZ, SGZ, the piriform cortex over layer II, and the amygdala around the PLN. The numerical densities of DCX+ neurons were reduced in all above neuroanatomical regions with age, particularly dramatic in the DG in the 5–6 years-old animals. Thus, DCX+ neurons are present in the two established neurogenic sites (SVZ and SGZ) in the Chinese tree shrew as seen in other mammals. DCX+ cortical neurons in this animal exhibit a topographic pattern comparable to that in mice and rats, while these immature neurons are also present in the amygdala, concentrating around the PLN as seen in primates and some nonprimate mammals. Frontiers Media S.A. 2021-09-16 /pmc/articles/PMC8481370/ /pubmed/34602987 http://dx.doi.org/10.3389/fnana.2021.727883 Text en Copyright © 2021 Ai, Luo, Tu, Yang, Jiang, Zhang, Bi, Tu, Yao and Yan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ai, Jia-Qi
Luo, Rongcan
Tu, Tian
Yang, Chen
Jiang, Juan
Zhang, Bo
Bi, Rui
Tu, Ewen
Yao, Yong-Gang
Yan, Xiao-Xin
Doublecortin-Expressing Neurons in Chinese Tree Shrew Forebrain Exhibit Mixed Rodent and Primate-Like Topographic Characteristics
title Doublecortin-Expressing Neurons in Chinese Tree Shrew Forebrain Exhibit Mixed Rodent and Primate-Like Topographic Characteristics
title_full Doublecortin-Expressing Neurons in Chinese Tree Shrew Forebrain Exhibit Mixed Rodent and Primate-Like Topographic Characteristics
title_fullStr Doublecortin-Expressing Neurons in Chinese Tree Shrew Forebrain Exhibit Mixed Rodent and Primate-Like Topographic Characteristics
title_full_unstemmed Doublecortin-Expressing Neurons in Chinese Tree Shrew Forebrain Exhibit Mixed Rodent and Primate-Like Topographic Characteristics
title_short Doublecortin-Expressing Neurons in Chinese Tree Shrew Forebrain Exhibit Mixed Rodent and Primate-Like Topographic Characteristics
title_sort doublecortin-expressing neurons in chinese tree shrew forebrain exhibit mixed rodent and primate-like topographic characteristics
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481370/
https://www.ncbi.nlm.nih.gov/pubmed/34602987
http://dx.doi.org/10.3389/fnana.2021.727883
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