Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function

Genome-wide association studies have identified numerous common genetic variants associated with spirometric measures of pulmonary function, including forced expiratory volume in one second (FEV(1)), forced vital capacity, and their ratio. However, variants with lower minor allele frequencies are le...

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Autores principales: Yang, Tianzhong, Jackson, Victoria E., Smith, Albert V., Chen, Han, Bartz, Traci M., Sitlani, Colleen M., Psaty, Bruce M., Gharib, Sina A., O’Connor, George T., Dupuis, Josée, Xu, Jiayi, Lohman, Kurt, Liu, Yongmei, Kritchevsky, Stephen B., Cassano, Patricia A., Flexeder, Claudia, Gieger, Christian, Karrasch, Stefan, Peters, Annette, Schulz, Holger, Harris, Sarah E., Starr, John M., Deary, Ian J., Manichaikul, Ani, Oelsner, Elizabeth C., Barr, R. G., Taylor, Kent D., Rich, Stephen S., Bonten, Tobias N., Mook-Kanamori, Dennis O., Noordam, Raymond, Li-Gao, Ruifang, Jarvelin, Marjo-Riitta, Wielscher, Matthias, Terzikhan, Natalie, Lahousse, Lies, Brusselle, Guy, Weiss, Stefan, Ewert, Ralf, Gläser, Sven, Homuth, Georg, Shrine, Nick, Hall, Ian P., Tobin, Martin, London, Stephanie J., Wei, Peng, Morrison, Alanna C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481467/
https://www.ncbi.nlm.nih.gov/pubmed/34588469
http://dx.doi.org/10.1038/s41598-021-98120-7

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