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Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections

Whether post injectional acute intraocular pressure (IOP) increase is associated with decreased peripapillary and macular perfusion is still under debate. Here, we investigated early changes in the choroidal and retinal blood flow using OCTA imaging in a cohort of patients undergoing anti-VEGF intra...

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Autores principales: Arumuganathan, Nadhini, Wiest, Maximilian Robert Justus, Toro, Mario Damiano, Hamann, Timothy, Fasler, Katrin, Zweifel, Sandrine Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481476/
https://www.ncbi.nlm.nih.gov/pubmed/34588594
http://dx.doi.org/10.1038/s41598-021-98850-8
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author Arumuganathan, Nadhini
Wiest, Maximilian Robert Justus
Toro, Mario Damiano
Hamann, Timothy
Fasler, Katrin
Zweifel, Sandrine Anne
author_facet Arumuganathan, Nadhini
Wiest, Maximilian Robert Justus
Toro, Mario Damiano
Hamann, Timothy
Fasler, Katrin
Zweifel, Sandrine Anne
author_sort Arumuganathan, Nadhini
collection PubMed
description Whether post injectional acute intraocular pressure (IOP) increase is associated with decreased peripapillary and macular perfusion is still under debate. Here, we investigated early changes in the choroidal and retinal blood flow using OCTA imaging in a cohort of patients undergoing anti-VEGF intravitreal injections (IVI) for macular edema following retinal vein occlusion and diabetic retinopathy. In this prospective single-center, observational study, the pre- and post-IVI changes in retinal perfusion were examined via assessment of vessel length density (VLD) and vessel density (VD) in deep and superficial capillary segmentations (DCP and SCP), foveal avascular zone (FAZ) in SCP, as well as flow signal deficits in the choriocapillaris segmentation. Mean IOP significantly changed over the study course (p = 0.000; ANOVA). Measurements at 5 min post-IVI (33.48 ± 10.84 mmHg) differed significantly from baseline (17.26 ± 2.41 mmHg, p = 0.000), while measurements from one day, one week, and one-month post-IVI did not (p = 0.907, p = 1.000 and p = 1.000 respectively). In comparison to baseline, no changes in OCTA parameters, including FAZ, VD, VLD, and FV, were detected 5 min post-IVI. No significant alterations in OCTA parameters were observed during study course. Increased IOP spikes were detected post-IVI; however, no potential permanent ischemic retinal damage was suspected.
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spelling pubmed-84814762021-10-01 Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections Arumuganathan, Nadhini Wiest, Maximilian Robert Justus Toro, Mario Damiano Hamann, Timothy Fasler, Katrin Zweifel, Sandrine Anne Sci Rep Article Whether post injectional acute intraocular pressure (IOP) increase is associated with decreased peripapillary and macular perfusion is still under debate. Here, we investigated early changes in the choroidal and retinal blood flow using OCTA imaging in a cohort of patients undergoing anti-VEGF intravitreal injections (IVI) for macular edema following retinal vein occlusion and diabetic retinopathy. In this prospective single-center, observational study, the pre- and post-IVI changes in retinal perfusion were examined via assessment of vessel length density (VLD) and vessel density (VD) in deep and superficial capillary segmentations (DCP and SCP), foveal avascular zone (FAZ) in SCP, as well as flow signal deficits in the choriocapillaris segmentation. Mean IOP significantly changed over the study course (p = 0.000; ANOVA). Measurements at 5 min post-IVI (33.48 ± 10.84 mmHg) differed significantly from baseline (17.26 ± 2.41 mmHg, p = 0.000), while measurements from one day, one week, and one-month post-IVI did not (p = 0.907, p = 1.000 and p = 1.000 respectively). In comparison to baseline, no changes in OCTA parameters, including FAZ, VD, VLD, and FV, were detected 5 min post-IVI. No significant alterations in OCTA parameters were observed during study course. Increased IOP spikes were detected post-IVI; however, no potential permanent ischemic retinal damage was suspected. Nature Publishing Group UK 2021-09-29 /pmc/articles/PMC8481476/ /pubmed/34588594 http://dx.doi.org/10.1038/s41598-021-98850-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Arumuganathan, Nadhini
Wiest, Maximilian Robert Justus
Toro, Mario Damiano
Hamann, Timothy
Fasler, Katrin
Zweifel, Sandrine Anne
Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
title Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
title_full Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
title_fullStr Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
title_full_unstemmed Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
title_short Acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
title_sort acute and subacute macular and peripapillary angiographic changes in choroidal and retinal blood flow post-intravitreal injections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481476/
https://www.ncbi.nlm.nih.gov/pubmed/34588594
http://dx.doi.org/10.1038/s41598-021-98850-8
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