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Translational opportunities in animal and human models to study alcohol use disorder

Animal and human laboratory paradigms offer invaluable approaches to study the complex etiologies and mechanisms of alcohol use disorder (AUD). We contend that human laboratory models provide a “bridge” between preclinical and clinical studies of AUD by allowing for well-controlled experimental mani...

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Autores principales: Nieto, Steven J., Grodin, Erica N., Aguirre, Claudia G., Izquierdo, Alicia, Ray, Lara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481537/
https://www.ncbi.nlm.nih.gov/pubmed/34588417
http://dx.doi.org/10.1038/s41398-021-01615-0
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author Nieto, Steven J.
Grodin, Erica N.
Aguirre, Claudia G.
Izquierdo, Alicia
Ray, Lara A.
author_facet Nieto, Steven J.
Grodin, Erica N.
Aguirre, Claudia G.
Izquierdo, Alicia
Ray, Lara A.
author_sort Nieto, Steven J.
collection PubMed
description Animal and human laboratory paradigms offer invaluable approaches to study the complex etiologies and mechanisms of alcohol use disorder (AUD). We contend that human laboratory models provide a “bridge” between preclinical and clinical studies of AUD by allowing for well-controlled experimental manipulations in humans with AUD. As such, examining the consilience between experimental models in animals and humans in the laboratory provides unique opportunities to refine the translational utility of such models. The overall goal of the present review is to provide a systematic description and contrast of commonly used animal paradigms for the study of AUD, as well as their human laboratory analogs if applicable. While there is a wide breadth of animal species in AUD research, the paradigms discussed in this review rely predominately on rodent research. The overarching goal of this effort is to provide critical analysis of these animal models and to link them to human laboratory models of AUD. By systematically contrasting preclinical and controlled human laboratory models, we seek to identify opportunities to enhance their translational value through forward and reverse translation. We provide future directions to reconcile differences between animal and human work and to improve translational research for AUD.
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spelling pubmed-84815372021-10-08 Translational opportunities in animal and human models to study alcohol use disorder Nieto, Steven J. Grodin, Erica N. Aguirre, Claudia G. Izquierdo, Alicia Ray, Lara A. Transl Psychiatry Review Article Animal and human laboratory paradigms offer invaluable approaches to study the complex etiologies and mechanisms of alcohol use disorder (AUD). We contend that human laboratory models provide a “bridge” between preclinical and clinical studies of AUD by allowing for well-controlled experimental manipulations in humans with AUD. As such, examining the consilience between experimental models in animals and humans in the laboratory provides unique opportunities to refine the translational utility of such models. The overall goal of the present review is to provide a systematic description and contrast of commonly used animal paradigms for the study of AUD, as well as their human laboratory analogs if applicable. While there is a wide breadth of animal species in AUD research, the paradigms discussed in this review rely predominately on rodent research. The overarching goal of this effort is to provide critical analysis of these animal models and to link them to human laboratory models of AUD. By systematically contrasting preclinical and controlled human laboratory models, we seek to identify opportunities to enhance their translational value through forward and reverse translation. We provide future directions to reconcile differences between animal and human work and to improve translational research for AUD. Nature Publishing Group UK 2021-09-29 /pmc/articles/PMC8481537/ /pubmed/34588417 http://dx.doi.org/10.1038/s41398-021-01615-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Nieto, Steven J.
Grodin, Erica N.
Aguirre, Claudia G.
Izquierdo, Alicia
Ray, Lara A.
Translational opportunities in animal and human models to study alcohol use disorder
title Translational opportunities in animal and human models to study alcohol use disorder
title_full Translational opportunities in animal and human models to study alcohol use disorder
title_fullStr Translational opportunities in animal and human models to study alcohol use disorder
title_full_unstemmed Translational opportunities in animal and human models to study alcohol use disorder
title_short Translational opportunities in animal and human models to study alcohol use disorder
title_sort translational opportunities in animal and human models to study alcohol use disorder
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481537/
https://www.ncbi.nlm.nih.gov/pubmed/34588417
http://dx.doi.org/10.1038/s41398-021-01615-0
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