Gastric proton pump with two occluded K(+) engineered with sodium pump-mimetic mutations

The gastric H(+),K(+)-ATPase mediates electroneutral exchange of 1H(+)/1K(+) per ATP hydrolysed across the membrane. Previous structural analysis of the K(+)-occluded E2-P transition state of H(+),K(+)-ATPase showed a single bound K(+) at cation-binding site II, in marked contrast to the two K(+) io...

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Detalles Bibliográficos
Autores principales: Abe, Kazuhiro, Yamamoto, Kenta, Irie, Katsumasa, Nishizawa, Tomohiro, Oshima, Atsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481561/
https://www.ncbi.nlm.nih.gov/pubmed/34588453
http://dx.doi.org/10.1038/s41467-021-26024-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481561/
https://www.ncbi.nlm.nih.gov/pubmed/34588453
http://dx.doi.org/10.1038/s41467-021-26024-1

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