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The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis
The N6-methyladenosine (m6A) modification is the most abundant epitranscriptomic modification in eukaryotic messenger RNA (mRNA). The m6A modification process is jointly regulated by various enzymes and proteins, such as methyltransferases, demethylases and related m6A-binding proteins. The process...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481608/ https://www.ncbi.nlm.nih.gov/pubmed/34603394 http://dx.doi.org/10.3389/fgene.2021.733871 |
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author | Fu, Jie Cui, Xinghui Zhang, Xiaoyun Cheng, Min Li, Xiaoxia Guo, Zhiliang Cui, Xiaodong |
author_facet | Fu, Jie Cui, Xinghui Zhang, Xiaoyun Cheng, Min Li, Xiaoxia Guo, Zhiliang Cui, Xiaodong |
author_sort | Fu, Jie |
collection | PubMed |
description | The N6-methyladenosine (m6A) modification is the most abundant epitranscriptomic modification in eukaryotic messenger RNA (mRNA). The m6A modification process is jointly regulated by various enzymes and proteins, such as methyltransferases, demethylases and related m6A-binding proteins. The process is dynamic and reversible, and it plays an essential role in mRNA metabolism and various biological activities. Recently, an increasing number of researchers have confirmed that the onset and development of many diseases are closely associated with the molecular biological mechanism of m6A RNA methylation. This study focuses on the relationship between m6A RNA modification and atherosclerosis (AS). It thoroughly summarizes the mechanisms and processes of m6A RNA modification in AS-related cells and the relationships between m6A RNA modification and AS risk factors, and it provides a reference for exploring new targets for the early diagnosis and treatment of AS. |
format | Online Article Text |
id | pubmed-8481608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84816082021-10-01 The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis Fu, Jie Cui, Xinghui Zhang, Xiaoyun Cheng, Min Li, Xiaoxia Guo, Zhiliang Cui, Xiaodong Front Genet Genetics The N6-methyladenosine (m6A) modification is the most abundant epitranscriptomic modification in eukaryotic messenger RNA (mRNA). The m6A modification process is jointly regulated by various enzymes and proteins, such as methyltransferases, demethylases and related m6A-binding proteins. The process is dynamic and reversible, and it plays an essential role in mRNA metabolism and various biological activities. Recently, an increasing number of researchers have confirmed that the onset and development of many diseases are closely associated with the molecular biological mechanism of m6A RNA methylation. This study focuses on the relationship between m6A RNA modification and atherosclerosis (AS). It thoroughly summarizes the mechanisms and processes of m6A RNA modification in AS-related cells and the relationships between m6A RNA modification and AS risk factors, and it provides a reference for exploring new targets for the early diagnosis and treatment of AS. Frontiers Media S.A. 2021-09-16 /pmc/articles/PMC8481608/ /pubmed/34603394 http://dx.doi.org/10.3389/fgene.2021.733871 Text en Copyright © 2021 Fu, Cui, Zhang, Cheng, Li, Guo and Cui. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Fu, Jie Cui, Xinghui Zhang, Xiaoyun Cheng, Min Li, Xiaoxia Guo, Zhiliang Cui, Xiaodong The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis |
title | The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis |
title_full | The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis |
title_fullStr | The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis |
title_full_unstemmed | The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis |
title_short | The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis |
title_sort | role of m6a ribonucleic acid modification in the occurrence of atherosclerosis |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481608/ https://www.ncbi.nlm.nih.gov/pubmed/34603394 http://dx.doi.org/10.3389/fgene.2021.733871 |
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