Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a common autoimmune connective tissue disease with unclear etiology and pathogenesis. Mesenchymal stem cell (MSC) and MSC derived extracellular vesicles (EVs) play important roles in regulating innate and adaptive immunity, which are involved in many physiologic...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Chunjuan, Sun, Jianmei, Tian, Yipeng, Li, Haibo, Zhang, Lili, Yang, Jinghan, Wang, Jinghua, Zhang, Jiaojiao, Yan, Shushan, Xu, Donghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481702/
https://www.ncbi.nlm.nih.gov/pubmed/34603289
http://dx.doi.org/10.3389/fimmu.2021.714832
_version_ 1784576736128663552
author Yang, Chunjuan
Sun, Jianmei
Tian, Yipeng
Li, Haibo
Zhang, Lili
Yang, Jinghan
Wang, Jinghua
Zhang, Jiaojiao
Yan, Shushan
Xu, Donghua
author_facet Yang, Chunjuan
Sun, Jianmei
Tian, Yipeng
Li, Haibo
Zhang, Lili
Yang, Jinghan
Wang, Jinghua
Zhang, Jiaojiao
Yan, Shushan
Xu, Donghua
author_sort Yang, Chunjuan
collection PubMed
description Systemic lupus erythematosus (SLE) is a common autoimmune connective tissue disease with unclear etiology and pathogenesis. Mesenchymal stem cell (MSC) and MSC derived extracellular vesicles (EVs) play important roles in regulating innate and adaptive immunity, which are involved in many physiological and pathological processes and contribute to the immune homeostasis in SLE. The effects of MSCs and EVs on SLE have been drawing more and more attention during the past few years. This article reviews the immunomodulatory effects and underlying mechanisms of MSC/MSC-EVs in SLE, which provides novel insight into understanding SLE pathogenesis and guiding the biological therapy.
format Online
Article
Text
id pubmed-8481702
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-84817022021-10-01 Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus Yang, Chunjuan Sun, Jianmei Tian, Yipeng Li, Haibo Zhang, Lili Yang, Jinghan Wang, Jinghua Zhang, Jiaojiao Yan, Shushan Xu, Donghua Front Immunol Immunology Systemic lupus erythematosus (SLE) is a common autoimmune connective tissue disease with unclear etiology and pathogenesis. Mesenchymal stem cell (MSC) and MSC derived extracellular vesicles (EVs) play important roles in regulating innate and adaptive immunity, which are involved in many physiological and pathological processes and contribute to the immune homeostasis in SLE. The effects of MSCs and EVs on SLE have been drawing more and more attention during the past few years. This article reviews the immunomodulatory effects and underlying mechanisms of MSC/MSC-EVs in SLE, which provides novel insight into understanding SLE pathogenesis and guiding the biological therapy. Frontiers Media S.A. 2021-09-16 /pmc/articles/PMC8481702/ /pubmed/34603289 http://dx.doi.org/10.3389/fimmu.2021.714832 Text en Copyright © 2021 Yang, Sun, Tian, Li, Zhang, Yang, Wang, Zhang, Yan and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yang, Chunjuan
Sun, Jianmei
Tian, Yipeng
Li, Haibo
Zhang, Lili
Yang, Jinghan
Wang, Jinghua
Zhang, Jiaojiao
Yan, Shushan
Xu, Donghua
Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus
title Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus
title_full Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus
title_fullStr Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus
title_full_unstemmed Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus
title_short Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus
title_sort immunomodulatory effect of mscs and mscs-derived extracellular vesicles in systemic lupus erythematosus
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481702/
https://www.ncbi.nlm.nih.gov/pubmed/34603289
http://dx.doi.org/10.3389/fimmu.2021.714832
work_keys_str_mv AT yangchunjuan immunomodulatoryeffectofmscsandmscsderivedextracellularvesiclesinsystemiclupuserythematosus
AT sunjianmei immunomodulatoryeffectofmscsandmscsderivedextracellularvesiclesinsystemiclupuserythematosus
AT tianyipeng immunomodulatoryeffectofmscsandmscsderivedextracellularvesiclesinsystemiclupuserythematosus
AT lihaibo immunomodulatoryeffectofmscsandmscsderivedextracellularvesiclesinsystemiclupuserythematosus
AT zhanglili immunomodulatoryeffectofmscsandmscsderivedextracellularvesiclesinsystemiclupuserythematosus
AT yangjinghan immunomodulatoryeffectofmscsandmscsderivedextracellularvesiclesinsystemiclupuserythematosus
AT wangjinghua immunomodulatoryeffectofmscsandmscsderivedextracellularvesiclesinsystemiclupuserythematosus
AT zhangjiaojiao immunomodulatoryeffectofmscsandmscsderivedextracellularvesiclesinsystemiclupuserythematosus
AT yanshushan immunomodulatoryeffectofmscsandmscsderivedextracellularvesiclesinsystemiclupuserythematosus
AT xudonghua immunomodulatoryeffectofmscsandmscsderivedextracellularvesiclesinsystemiclupuserythematosus

Ejemplares similares