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Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation
We propose and investigate a biosensor based on a transparent dielectric-modulated dual-trench gate-engineered metal–oxide–semiconductor field-effect transistor (DM DT GE-MOSFET) for label-free detection of biomolecules with enhanced sensitivity and efficiency. Various sensing parameters such as the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481763/ https://www.ncbi.nlm.nih.gov/pubmed/34608380 http://dx.doi.org/10.1007/s10825-021-01780-x |
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author | Sen, Dipanjan De, Arpan Goswami, Bijoy Shee, Sharmistha Sarkar, Subir Kumar |
author_facet | Sen, Dipanjan De, Arpan Goswami, Bijoy Shee, Sharmistha Sarkar, Subir Kumar |
author_sort | Sen, Dipanjan |
collection | PubMed |
description | We propose and investigate a biosensor based on a transparent dielectric-modulated dual-trench gate-engineered metal–oxide–semiconductor field-effect transistor (DM DT GE-MOSFET) for label-free detection of biomolecules with enhanced sensitivity and efficiency. Various sensing parameters such as the I(ON)/I(OFF) ratio and the threshold voltage shift are evaluated as metrics to validate the proposed sensing device. Additionally, S(Vth) (the V(th) sensitivity) is also analyzed, considering both positively and negatively charged biomolecules. In addition, radiofrequency (RF) sensing parameters such as the transconductance gain and the cutoff frequency are taken into account to provide further insight into the sensitivity of the proposed device. Furthermore, the linearity, distortion, and noise immunity of the device are evaluated to confirm the overall performance of the biosensor at high (GHz) frequency. The results indicate that the proposed biosensor exhibits a S(Vth) value of 0.68 for positively charged biomolecules at a very low drain bias of 0.2 V. The proposed device can thus be used as an alternative to conventional FET-based biosensors. |
format | Online Article Text |
id | pubmed-8481763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-84817632021-09-30 Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation Sen, Dipanjan De, Arpan Goswami, Bijoy Shee, Sharmistha Sarkar, Subir Kumar J Comput Electron Article We propose and investigate a biosensor based on a transparent dielectric-modulated dual-trench gate-engineered metal–oxide–semiconductor field-effect transistor (DM DT GE-MOSFET) for label-free detection of biomolecules with enhanced sensitivity and efficiency. Various sensing parameters such as the I(ON)/I(OFF) ratio and the threshold voltage shift are evaluated as metrics to validate the proposed sensing device. Additionally, S(Vth) (the V(th) sensitivity) is also analyzed, considering both positively and negatively charged biomolecules. In addition, radiofrequency (RF) sensing parameters such as the transconductance gain and the cutoff frequency are taken into account to provide further insight into the sensitivity of the proposed device. Furthermore, the linearity, distortion, and noise immunity of the device are evaluated to confirm the overall performance of the biosensor at high (GHz) frequency. The results indicate that the proposed biosensor exhibits a S(Vth) value of 0.68 for positively charged biomolecules at a very low drain bias of 0.2 V. The proposed device can thus be used as an alternative to conventional FET-based biosensors. Springer US 2021-09-30 2021 /pmc/articles/PMC8481763/ /pubmed/34608380 http://dx.doi.org/10.1007/s10825-021-01780-x Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Sen, Dipanjan De, Arpan Goswami, Bijoy Shee, Sharmistha Sarkar, Subir Kumar Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation |
title | Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation |
title_full | Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation |
title_fullStr | Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation |
title_full_unstemmed | Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation |
title_short | Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation |
title_sort | noise immune dielectric modulated dual trench transparent gate engineered mosfet as a label free biosensor: proposal and investigation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481763/ https://www.ncbi.nlm.nih.gov/pubmed/34608380 http://dx.doi.org/10.1007/s10825-021-01780-x |
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