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Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation

We propose and investigate a biosensor based on a transparent dielectric-modulated dual-trench gate-engineered metal–oxide–semiconductor field-effect transistor (DM DT GE-MOSFET) for label-free detection of biomolecules with enhanced sensitivity and efficiency. Various sensing parameters such as the...

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Detalles Bibliográficos
Autores principales: Sen, Dipanjan, De, Arpan, Goswami, Bijoy, Shee, Sharmistha, Sarkar, Subir Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481763/
https://www.ncbi.nlm.nih.gov/pubmed/34608380
http://dx.doi.org/10.1007/s10825-021-01780-x
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author Sen, Dipanjan
De, Arpan
Goswami, Bijoy
Shee, Sharmistha
Sarkar, Subir Kumar
author_facet Sen, Dipanjan
De, Arpan
Goswami, Bijoy
Shee, Sharmistha
Sarkar, Subir Kumar
author_sort Sen, Dipanjan
collection PubMed
description We propose and investigate a biosensor based on a transparent dielectric-modulated dual-trench gate-engineered metal–oxide–semiconductor field-effect transistor (DM DT GE-MOSFET) for label-free detection of biomolecules with enhanced sensitivity and efficiency. Various sensing parameters such as the I(ON)/I(OFF) ratio and the threshold voltage shift are evaluated as metrics to validate the proposed sensing device. Additionally, S(Vth) (the V(th) sensitivity) is also analyzed, considering both positively and negatively charged biomolecules. In addition, radiofrequency (RF) sensing parameters such as the transconductance gain and the cutoff frequency are taken into account to provide further insight into the sensitivity of the proposed device. Furthermore, the linearity, distortion, and noise immunity of the device are evaluated to confirm the overall performance of the biosensor at high (GHz) frequency. The results indicate that the proposed biosensor exhibits a S(Vth) value of 0.68 for positively charged biomolecules at a very low drain bias of 0.2 V. The proposed device can thus be used as an alternative to conventional FET-based biosensors.
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spelling pubmed-84817632021-09-30 Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation Sen, Dipanjan De, Arpan Goswami, Bijoy Shee, Sharmistha Sarkar, Subir Kumar J Comput Electron Article We propose and investigate a biosensor based on a transparent dielectric-modulated dual-trench gate-engineered metal–oxide–semiconductor field-effect transistor (DM DT GE-MOSFET) for label-free detection of biomolecules with enhanced sensitivity and efficiency. Various sensing parameters such as the I(ON)/I(OFF) ratio and the threshold voltage shift are evaluated as metrics to validate the proposed sensing device. Additionally, S(Vth) (the V(th) sensitivity) is also analyzed, considering both positively and negatively charged biomolecules. In addition, radiofrequency (RF) sensing parameters such as the transconductance gain and the cutoff frequency are taken into account to provide further insight into the sensitivity of the proposed device. Furthermore, the linearity, distortion, and noise immunity of the device are evaluated to confirm the overall performance of the biosensor at high (GHz) frequency. The results indicate that the proposed biosensor exhibits a S(Vth) value of 0.68 for positively charged biomolecules at a very low drain bias of 0.2 V. The proposed device can thus be used as an alternative to conventional FET-based biosensors. Springer US 2021-09-30 2021 /pmc/articles/PMC8481763/ /pubmed/34608380 http://dx.doi.org/10.1007/s10825-021-01780-x Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Sen, Dipanjan
De, Arpan
Goswami, Bijoy
Shee, Sharmistha
Sarkar, Subir Kumar
Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation
title Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation
title_full Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation
title_fullStr Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation
title_full_unstemmed Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation
title_short Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation
title_sort noise immune dielectric modulated dual trench transparent gate engineered mosfet as a label free biosensor: proposal and investigation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481763/
https://www.ncbi.nlm.nih.gov/pubmed/34608380
http://dx.doi.org/10.1007/s10825-021-01780-x
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