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Stimulus-Specific Expression, Selective Generation and Novel Function of Grass Carp (Ctenopharyngodon idella) IL-12 Isoforms: New Insights Into the Heterodimeric Cytokines in Teleosts

Interleukin-12 (IL-12) is a heterodimeric cytokine composed of a p35 subunit specific to IL-12 and a p40 subunit shared with IL-23. In this study, we unveiled the existence of two p35 paralogues in grass carp (named gcp35a and gcp35b). Notably, gcp35a and gcp35b displayed distinct inducible expressi...

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Detalles Bibliográficos
Autores principales:	Qiu, Xingyang, Sun, Hao, Wang, Dan, Ren, Jingqi, Wang, Xinyan, Zhang, Anying, Yang, Kun, Zhou, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481787/ https://www.ncbi.nlm.nih.gov/pubmed/34603315 http://dx.doi.org/10.3389/fimmu.2021.734535

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