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Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies

In the last decades, biomedical research has significantly boomed in the academia and industrial sectors, and it is expected to continue to grow at a rapid pace in the future. An in-depth analysis of such growth is not trivial, given the intrinsic multidisciplinary nature of biomedical research. Nev...

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Autores principales: Celikkin, Nehar, Presutti, Dario, Maiullari, Fabio, Fornetti, Ersilia, Agarwal, Tarun, Paradiso, Alessia, Volpi, Marina, Święszkowski, Wojciech, Bearzi, Claudia, Barbetta, Andrea, Zhang, Yu Shrike, Gargioli, Cesare, Rizzi, Roberto, Costantini, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481890/
https://www.ncbi.nlm.nih.gov/pubmed/34604190
http://dx.doi.org/10.3389/fbioe.2021.732130
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author Celikkin, Nehar
Presutti, Dario
Maiullari, Fabio
Fornetti, Ersilia
Agarwal, Tarun
Paradiso, Alessia
Volpi, Marina
Święszkowski, Wojciech
Bearzi, Claudia
Barbetta, Andrea
Zhang, Yu Shrike
Gargioli, Cesare
Rizzi, Roberto
Costantini, Marco
author_facet Celikkin, Nehar
Presutti, Dario
Maiullari, Fabio
Fornetti, Ersilia
Agarwal, Tarun
Paradiso, Alessia
Volpi, Marina
Święszkowski, Wojciech
Bearzi, Claudia
Barbetta, Andrea
Zhang, Yu Shrike
Gargioli, Cesare
Rizzi, Roberto
Costantini, Marco
author_sort Celikkin, Nehar
collection PubMed
description In the last decades, biomedical research has significantly boomed in the academia and industrial sectors, and it is expected to continue to grow at a rapid pace in the future. An in-depth analysis of such growth is not trivial, given the intrinsic multidisciplinary nature of biomedical research. Nevertheless, technological advances are among the main factors which have enabled such progress. In this review, we discuss the contribution of two state-of-the-art technologies–namely biofabrication and organ-on-a-chip–in a selection of biomedical research areas. We start by providing an overview of these technologies and their capacities in fabricating advanced in vitro tissue/organ models. We then analyze their impact on addressing a range of current biomedical challenges. Ultimately, we speculate about their future developments by integrating these technologies with other cutting-edge research fields such as artificial intelligence and big data analysis.
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spelling pubmed-84818902021-10-01 Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies Celikkin, Nehar Presutti, Dario Maiullari, Fabio Fornetti, Ersilia Agarwal, Tarun Paradiso, Alessia Volpi, Marina Święszkowski, Wojciech Bearzi, Claudia Barbetta, Andrea Zhang, Yu Shrike Gargioli, Cesare Rizzi, Roberto Costantini, Marco Front Bioeng Biotechnol Bioengineering and Biotechnology In the last decades, biomedical research has significantly boomed in the academia and industrial sectors, and it is expected to continue to grow at a rapid pace in the future. An in-depth analysis of such growth is not trivial, given the intrinsic multidisciplinary nature of biomedical research. Nevertheless, technological advances are among the main factors which have enabled such progress. In this review, we discuss the contribution of two state-of-the-art technologies–namely biofabrication and organ-on-a-chip–in a selection of biomedical research areas. We start by providing an overview of these technologies and their capacities in fabricating advanced in vitro tissue/organ models. We then analyze their impact on addressing a range of current biomedical challenges. Ultimately, we speculate about their future developments by integrating these technologies with other cutting-edge research fields such as artificial intelligence and big data analysis. Frontiers Media S.A. 2021-09-16 /pmc/articles/PMC8481890/ /pubmed/34604190 http://dx.doi.org/10.3389/fbioe.2021.732130 Text en Copyright © 2021 Celikkin, Presutti, Maiullari, Fornetti, Agarwal, Paradiso, Volpi, Święszkowski, Bearzi, Barbetta, Zhang, Gargioli, Rizzi and Costantini. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Celikkin, Nehar
Presutti, Dario
Maiullari, Fabio
Fornetti, Ersilia
Agarwal, Tarun
Paradiso, Alessia
Volpi, Marina
Święszkowski, Wojciech
Bearzi, Claudia
Barbetta, Andrea
Zhang, Yu Shrike
Gargioli, Cesare
Rizzi, Roberto
Costantini, Marco
Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies
title Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies
title_full Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies
title_fullStr Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies
title_full_unstemmed Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies
title_short Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies
title_sort tackling current biomedical challenges with frontier biofabrication and organ-on-a-chip technologies
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481890/
https://www.ncbi.nlm.nih.gov/pubmed/34604190
http://dx.doi.org/10.3389/fbioe.2021.732130
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