Dual-Antigen COVID-19 Vaccine Subcutaneous Prime Delivery With Oral Boosts Protects NHP Against SARS-CoV-2 Challenge

We have developed a dual-antigen COVID-19 vaccine incorporating genes for a modified SARS-CoV-2 spike protein (S-Fusion) and the viral nucleocapsid (N) protein with an Enhanced T-cell Stimulation Domain (N-ETSD) to increase the potential for MHC class II responses. The vaccine antigens are delivered...

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Detalles Bibliográficos
Autores principales: Gabitzsch, Elizabeth, Safrit, Jeffrey T., Verma, Mohit, Rice, Adrian, Sieling, Peter, Zakin, Lise, Shin, Annie, Morimoto, Brett, Adisetiyo, Helty, Wong, Raymond, Bezawada, Ashish, Dinkins, Kyle, Balint, Joseph, Peykov, Victor, Garban, Hermes, Liu, Philip, Bacon, Andrew, Bone, Pete, Drew, Jeff, Sanford, Daniel C., Spilman, Patricia, Sender, Lennie, Rabizadeh, Shahrooz, Niazi, Kayvan, Soon-Shiong, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481919/
https://www.ncbi.nlm.nih.gov/pubmed/34603305
http://dx.doi.org/10.3389/fimmu.2021.729837

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