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Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year

Severe community-acquired pneumonia (sCAP) early in life is a leading cause of morbidity, mortality, and irreversible sequelae. Herein, we report the clinical, etiological, and immunological characteristics of 62 children age < 1 year. We measured 27 cytokines in plasma and bronchoalveolar lavage...

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Detalles Bibliográficos
Autores principales: Liu, Ming, Lu, Bingtai, Fan, Huifeng, Guo, Xuanjie, Du, Shuling, Yang, Diyuan, Xu, Yiping, Li, Yue, Che, Di, Liu, Yunfeng, Gu, Xiaoqiong, Ding, Tao, Wang, Ping, Luo, Hai-bin, Lu, Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482031/
https://www.ncbi.nlm.nih.gov/pubmed/34602860
http://dx.doi.org/10.1155/2021/9955168
Descripción
Sumario:Severe community-acquired pneumonia (sCAP) early in life is a leading cause of morbidity, mortality, and irreversible sequelae. Herein, we report the clinical, etiological, and immunological characteristics of 62 children age < 1 year. We measured 27 cytokines in plasma and bronchoalveolar lavage (BAL) from 62 children age < 1 year who were diagnosed with CAP, and then, we analyzed correlations among disease severity, clinical parameters, and etiology. Of the entire cohort, three cytokines associated with interleukin-17- (IL-17-) producing helper T cells (T(h)17 cells), IL-1β, IL-6, and IL-17, were significantly elevated in sCAP patients with high fold changes (FCs); in BAL, these cytokines were intercorrelated and associated with blood neutrophil counts, Hb levels, and mixed bacterial-viral infections. BAL IL-1β (area under the curve (AUC) 0.820), BAL IL-17 (AUC 0.779), and plasma IL-6 (AUC 0.778) had remarkable predictive power for sCAP. Our findings revealed that increased local T(h)17 cell immunity played a critical role in the development of sCAP in children age < 1 year. T(h)17 cell-related cytokines could serve as local and systemic inflammatory indicators of sCAP in this age group.