Cargando…
Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year
Severe community-acquired pneumonia (sCAP) early in life is a leading cause of morbidity, mortality, and irreversible sequelae. Herein, we report the clinical, etiological, and immunological characteristics of 62 children age < 1 year. We measured 27 cytokines in plasma and bronchoalveolar lavage...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482031/ https://www.ncbi.nlm.nih.gov/pubmed/34602860 http://dx.doi.org/10.1155/2021/9955168 |
_version_ | 1784576808990015488 |
---|---|
author | Liu, Ming Lu, Bingtai Fan, Huifeng Guo, Xuanjie Du, Shuling Yang, Diyuan Xu, Yiping Li, Yue Che, Di Liu, Yunfeng Gu, Xiaoqiong Ding, Tao Wang, Ping Luo, Hai-bin Lu, Gen |
author_facet | Liu, Ming Lu, Bingtai Fan, Huifeng Guo, Xuanjie Du, Shuling Yang, Diyuan Xu, Yiping Li, Yue Che, Di Liu, Yunfeng Gu, Xiaoqiong Ding, Tao Wang, Ping Luo, Hai-bin Lu, Gen |
author_sort | Liu, Ming |
collection | PubMed |
description | Severe community-acquired pneumonia (sCAP) early in life is a leading cause of morbidity, mortality, and irreversible sequelae. Herein, we report the clinical, etiological, and immunological characteristics of 62 children age < 1 year. We measured 27 cytokines in plasma and bronchoalveolar lavage (BAL) from 62 children age < 1 year who were diagnosed with CAP, and then, we analyzed correlations among disease severity, clinical parameters, and etiology. Of the entire cohort, three cytokines associated with interleukin-17- (IL-17-) producing helper T cells (T(h)17 cells), IL-1β, IL-6, and IL-17, were significantly elevated in sCAP patients with high fold changes (FCs); in BAL, these cytokines were intercorrelated and associated with blood neutrophil counts, Hb levels, and mixed bacterial-viral infections. BAL IL-1β (area under the curve (AUC) 0.820), BAL IL-17 (AUC 0.779), and plasma IL-6 (AUC 0.778) had remarkable predictive power for sCAP. Our findings revealed that increased local T(h)17 cell immunity played a critical role in the development of sCAP in children age < 1 year. T(h)17 cell-related cytokines could serve as local and systemic inflammatory indicators of sCAP in this age group. |
format | Online Article Text |
id | pubmed-8482031 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-84820312021-10-01 Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year Liu, Ming Lu, Bingtai Fan, Huifeng Guo, Xuanjie Du, Shuling Yang, Diyuan Xu, Yiping Li, Yue Che, Di Liu, Yunfeng Gu, Xiaoqiong Ding, Tao Wang, Ping Luo, Hai-bin Lu, Gen Mediators Inflamm Research Article Severe community-acquired pneumonia (sCAP) early in life is a leading cause of morbidity, mortality, and irreversible sequelae. Herein, we report the clinical, etiological, and immunological characteristics of 62 children age < 1 year. We measured 27 cytokines in plasma and bronchoalveolar lavage (BAL) from 62 children age < 1 year who were diagnosed with CAP, and then, we analyzed correlations among disease severity, clinical parameters, and etiology. Of the entire cohort, three cytokines associated with interleukin-17- (IL-17-) producing helper T cells (T(h)17 cells), IL-1β, IL-6, and IL-17, were significantly elevated in sCAP patients with high fold changes (FCs); in BAL, these cytokines were intercorrelated and associated with blood neutrophil counts, Hb levels, and mixed bacterial-viral infections. BAL IL-1β (area under the curve (AUC) 0.820), BAL IL-17 (AUC 0.779), and plasma IL-6 (AUC 0.778) had remarkable predictive power for sCAP. Our findings revealed that increased local T(h)17 cell immunity played a critical role in the development of sCAP in children age < 1 year. T(h)17 cell-related cytokines could serve as local and systemic inflammatory indicators of sCAP in this age group. Hindawi 2021-09-22 /pmc/articles/PMC8482031/ /pubmed/34602860 http://dx.doi.org/10.1155/2021/9955168 Text en Copyright © 2021 Ming Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Ming Lu, Bingtai Fan, Huifeng Guo, Xuanjie Du, Shuling Yang, Diyuan Xu, Yiping Li, Yue Che, Di Liu, Yunfeng Gu, Xiaoqiong Ding, Tao Wang, Ping Luo, Hai-bin Lu, Gen Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year |
title | Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year |
title_full | Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year |
title_fullStr | Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year |
title_full_unstemmed | Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year |
title_short | Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year |
title_sort | heightened local t(h)17 cell inflammation is associated with severe community-acquired pneumonia in children under the age of 1 year |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482031/ https://www.ncbi.nlm.nih.gov/pubmed/34602860 http://dx.doi.org/10.1155/2021/9955168 |
work_keys_str_mv | AT liuming heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT lubingtai heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT fanhuifeng heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT guoxuanjie heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT dushuling heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT yangdiyuan heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT xuyiping heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT liyue heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT chedi heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT liuyunfeng heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT guxiaoqiong heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT dingtao heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT wangping heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT luohaibin heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year AT lugen heightenedlocalth17cellinflammationisassociatedwithseverecommunityacquiredpneumoniainchildrenundertheageof1year |