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Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year

Severe community-acquired pneumonia (sCAP) early in life is a leading cause of morbidity, mortality, and irreversible sequelae. Herein, we report the clinical, etiological, and immunological characteristics of 62 children age < 1 year. We measured 27 cytokines in plasma and bronchoalveolar lavage...

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Autores principales: Liu, Ming, Lu, Bingtai, Fan, Huifeng, Guo, Xuanjie, Du, Shuling, Yang, Diyuan, Xu, Yiping, Li, Yue, Che, Di, Liu, Yunfeng, Gu, Xiaoqiong, Ding, Tao, Wang, Ping, Luo, Hai-bin, Lu, Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482031/
https://www.ncbi.nlm.nih.gov/pubmed/34602860
http://dx.doi.org/10.1155/2021/9955168
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author Liu, Ming
Lu, Bingtai
Fan, Huifeng
Guo, Xuanjie
Du, Shuling
Yang, Diyuan
Xu, Yiping
Li, Yue
Che, Di
Liu, Yunfeng
Gu, Xiaoqiong
Ding, Tao
Wang, Ping
Luo, Hai-bin
Lu, Gen
author_facet Liu, Ming
Lu, Bingtai
Fan, Huifeng
Guo, Xuanjie
Du, Shuling
Yang, Diyuan
Xu, Yiping
Li, Yue
Che, Di
Liu, Yunfeng
Gu, Xiaoqiong
Ding, Tao
Wang, Ping
Luo, Hai-bin
Lu, Gen
author_sort Liu, Ming
collection PubMed
description Severe community-acquired pneumonia (sCAP) early in life is a leading cause of morbidity, mortality, and irreversible sequelae. Herein, we report the clinical, etiological, and immunological characteristics of 62 children age < 1 year. We measured 27 cytokines in plasma and bronchoalveolar lavage (BAL) from 62 children age < 1 year who were diagnosed with CAP, and then, we analyzed correlations among disease severity, clinical parameters, and etiology. Of the entire cohort, three cytokines associated with interleukin-17- (IL-17-) producing helper T cells (T(h)17 cells), IL-1β, IL-6, and IL-17, were significantly elevated in sCAP patients with high fold changes (FCs); in BAL, these cytokines were intercorrelated and associated with blood neutrophil counts, Hb levels, and mixed bacterial-viral infections. BAL IL-1β (area under the curve (AUC) 0.820), BAL IL-17 (AUC 0.779), and plasma IL-6 (AUC 0.778) had remarkable predictive power for sCAP. Our findings revealed that increased local T(h)17 cell immunity played a critical role in the development of sCAP in children age < 1 year. T(h)17 cell-related cytokines could serve as local and systemic inflammatory indicators of sCAP in this age group.
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spelling pubmed-84820312021-10-01 Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year Liu, Ming Lu, Bingtai Fan, Huifeng Guo, Xuanjie Du, Shuling Yang, Diyuan Xu, Yiping Li, Yue Che, Di Liu, Yunfeng Gu, Xiaoqiong Ding, Tao Wang, Ping Luo, Hai-bin Lu, Gen Mediators Inflamm Research Article Severe community-acquired pneumonia (sCAP) early in life is a leading cause of morbidity, mortality, and irreversible sequelae. Herein, we report the clinical, etiological, and immunological characteristics of 62 children age < 1 year. We measured 27 cytokines in plasma and bronchoalveolar lavage (BAL) from 62 children age < 1 year who were diagnosed with CAP, and then, we analyzed correlations among disease severity, clinical parameters, and etiology. Of the entire cohort, three cytokines associated with interleukin-17- (IL-17-) producing helper T cells (T(h)17 cells), IL-1β, IL-6, and IL-17, were significantly elevated in sCAP patients with high fold changes (FCs); in BAL, these cytokines were intercorrelated and associated with blood neutrophil counts, Hb levels, and mixed bacterial-viral infections. BAL IL-1β (area under the curve (AUC) 0.820), BAL IL-17 (AUC 0.779), and plasma IL-6 (AUC 0.778) had remarkable predictive power for sCAP. Our findings revealed that increased local T(h)17 cell immunity played a critical role in the development of sCAP in children age < 1 year. T(h)17 cell-related cytokines could serve as local and systemic inflammatory indicators of sCAP in this age group. Hindawi 2021-09-22 /pmc/articles/PMC8482031/ /pubmed/34602860 http://dx.doi.org/10.1155/2021/9955168 Text en Copyright © 2021 Ming Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Ming
Lu, Bingtai
Fan, Huifeng
Guo, Xuanjie
Du, Shuling
Yang, Diyuan
Xu, Yiping
Li, Yue
Che, Di
Liu, Yunfeng
Gu, Xiaoqiong
Ding, Tao
Wang, Ping
Luo, Hai-bin
Lu, Gen
Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year
title Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year
title_full Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year
title_fullStr Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year
title_full_unstemmed Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year
title_short Heightened Local T(h)17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year
title_sort heightened local t(h)17 cell inflammation is associated with severe community-acquired pneumonia in children under the age of 1 year
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482031/
https://www.ncbi.nlm.nih.gov/pubmed/34602860
http://dx.doi.org/10.1155/2021/9955168
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