Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms

The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the...

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Autores principales: Frega, G., Kepp, O., Turchetti, D., Rizzo, A., Pantaleo, M.A., Brandi, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482038/
https://www.ncbi.nlm.nih.gov/pubmed/34592590
http://dx.doi.org/10.1016/j.tranon.2021.101224
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author Frega, G.
Kepp, O.
Turchetti, D.
Rizzo, A.
Pantaleo, M.A.
Brandi, G.
author_facet Frega, G.
Kepp, O.
Turchetti, D.
Rizzo, A.
Pantaleo, M.A.
Brandi, G.
author_sort Frega, G.
collection PubMed
description The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than non-gestational trophoblastic neoplasm (nGTN). Due to its peculiar genetic inheritance, GTN potentially constitutes a singular archetype in the immuno-oncological field.
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spelling pubmed-84820382021-10-07 Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms Frega, G. Kepp, O. Turchetti, D. Rizzo, A. Pantaleo, M.A. Brandi, G. Transl Oncol Commentary The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than non-gestational trophoblastic neoplasm (nGTN). Due to its peculiar genetic inheritance, GTN potentially constitutes a singular archetype in the immuno-oncological field. Neoplasia Press 2021-09-27 /pmc/articles/PMC8482038/ /pubmed/34592590 http://dx.doi.org/10.1016/j.tranon.2021.101224 Text en © 2021 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Commentary
Frega, G.
Kepp, O.
Turchetti, D.
Rizzo, A.
Pantaleo, M.A.
Brandi, G.
Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
title Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
title_full Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
title_fullStr Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
title_full_unstemmed Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
title_short Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
title_sort hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482038/
https://www.ncbi.nlm.nih.gov/pubmed/34592590
http://dx.doi.org/10.1016/j.tranon.2021.101224
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