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Symptoms and Health Outcomes Among Survivors of COVID-19 Infection 1 Year After Discharge From Hospitals in Wuhan, China

IMPORTANCE: The long-term health outcomes and symptom burden of COVID-19 remain largely unclear. OBJECTIVE: To evaluate health outcomes of COVID-19 survivors 1 year after hospital discharge and to identify associated risk factors. DESIGN, SETTING, AND PARTICIPANTS: This retrospective, multicenter co...

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Autores principales: Zhang, Xue, Wang, Fang, Shen, Ye, Zhang, Xiaohua, Cen, Yuan, Wang, Bin, Zhao, Songtao, Zhou, Yi, Hu, Baoman, Wang, Man, Liu, Yuhui, Miao, Hongming, Jones, Paul, Ma, Xiangyu, He, Yong, Cao, Guoqiang, Cheng, Lixia, Li, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482055/
https://www.ncbi.nlm.nih.gov/pubmed/34586367
http://dx.doi.org/10.1001/jamanetworkopen.2021.27403
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author Zhang, Xue
Wang, Fang
Shen, Ye
Zhang, Xiaohua
Cen, Yuan
Wang, Bin
Zhao, Songtao
Zhou, Yi
Hu, Baoman
Wang, Man
Liu, Yuhui
Miao, Hongming
Jones, Paul
Ma, Xiangyu
He, Yong
Cao, Guoqiang
Cheng, Lixia
Li, Li
author_facet Zhang, Xue
Wang, Fang
Shen, Ye
Zhang, Xiaohua
Cen, Yuan
Wang, Bin
Zhao, Songtao
Zhou, Yi
Hu, Baoman
Wang, Man
Liu, Yuhui
Miao, Hongming
Jones, Paul
Ma, Xiangyu
He, Yong
Cao, Guoqiang
Cheng, Lixia
Li, Li
author_sort Zhang, Xue
collection PubMed
description IMPORTANCE: The long-term health outcomes and symptom burden of COVID-19 remain largely unclear. OBJECTIVE: To evaluate health outcomes of COVID-19 survivors 1 year after hospital discharge and to identify associated risk factors. DESIGN, SETTING, AND PARTICIPANTS: This retrospective, multicenter cohort study was conducted at 2 designated hospitals, Huoshenshan Hospital and Taikang Tongji Hospital, both in Wuhan, China. All adult patients with COVID-19 discharged between February 12 and April 10, 2020, were screened for eligibility. Of a consecutive sample of 3988 discharged patients, 1555 were excluded (796 declined to participate and 759 were unable to be contacted) and the remaining 2433 patients were enrolled. All patients were interviewed via telephone from March 1 to March 20, 2021. Statistical analysis was performed from March 28 to April 18, 2021. EXPOSURES: COVID-19. MAIN OUTCOMES AND MEASURES: All patients participated in telephone interviews using a series of questionnaires for evaluation of symptoms, along with a chronic obstructive pulmonary disease (COPD) assessment test (CAT). Logistic regression models were used to evaluate risk factors for fatigue, dyspnea, symptom burden, or higher CAT scores. RESULTS: Of 2433 patients at 1-year follow-up, 1205 (49.5%) were men and 680 (27.9%) were categorized into the severe disease group as defined by the World Health Organization guideline; the median (IQR) age was 60.0 (49.0-68.0) years. In total, 1095 patients (45.0%) reported at least 1 symptom. The most common symptoms included fatigue, sweating, chest tightness, anxiety, and myalgia. Older age (odds ratio [OR], 1.02; 95% CI, 1.01-1.02; P < .001), female sex (OR, 1.27; 95% CI, 1.06-1.52; P = .008), and severe disease during hospital stay (OR, 1.43; 95% CI, 1.18-1.74; P < .001) were associated with higher risks of fatigue. Older age (OR, 1.02; 95% CI, 1.01-1.03; P < .001) and severe disease (OR, 1.51; 95% CI, 1.14-1.99; P = .004) were associated with higher risks of having at least 3 symptoms. The median (IQR) CAT score was 2 (0-4), and a total of 161 patients (6.6%) had a CAT score of at least 10. Severe disease (OR, 1.84; 95% CI, 1.31-2.58; P < .001) and coexisting cerebrovascular diseases (OR, 1.95; 95% CI, 1.07-3.54; P = .03) were independent risk factors for CAT scores of at least 10. CONCLUSIONS AND RELEVANCE: This study found that patients with COVID-19 with severe disease during hospitalization had more postinfection symptoms and higher CAT scores.
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spelling pubmed-84820552021-10-08 Symptoms and Health Outcomes Among Survivors of COVID-19 Infection 1 Year After Discharge From Hospitals in Wuhan, China Zhang, Xue Wang, Fang Shen, Ye Zhang, Xiaohua Cen, Yuan Wang, Bin Zhao, Songtao Zhou, Yi Hu, Baoman Wang, Man Liu, Yuhui Miao, Hongming Jones, Paul Ma, Xiangyu He, Yong Cao, Guoqiang Cheng, Lixia Li, Li JAMA Netw Open Original Investigation IMPORTANCE: The long-term health outcomes and symptom burden of COVID-19 remain largely unclear. OBJECTIVE: To evaluate health outcomes of COVID-19 survivors 1 year after hospital discharge and to identify associated risk factors. DESIGN, SETTING, AND PARTICIPANTS: This retrospective, multicenter cohort study was conducted at 2 designated hospitals, Huoshenshan Hospital and Taikang Tongji Hospital, both in Wuhan, China. All adult patients with COVID-19 discharged between February 12 and April 10, 2020, were screened for eligibility. Of a consecutive sample of 3988 discharged patients, 1555 were excluded (796 declined to participate and 759 were unable to be contacted) and the remaining 2433 patients were enrolled. All patients were interviewed via telephone from March 1 to March 20, 2021. Statistical analysis was performed from March 28 to April 18, 2021. EXPOSURES: COVID-19. MAIN OUTCOMES AND MEASURES: All patients participated in telephone interviews using a series of questionnaires for evaluation of symptoms, along with a chronic obstructive pulmonary disease (COPD) assessment test (CAT). Logistic regression models were used to evaluate risk factors for fatigue, dyspnea, symptom burden, or higher CAT scores. RESULTS: Of 2433 patients at 1-year follow-up, 1205 (49.5%) were men and 680 (27.9%) were categorized into the severe disease group as defined by the World Health Organization guideline; the median (IQR) age was 60.0 (49.0-68.0) years. In total, 1095 patients (45.0%) reported at least 1 symptom. The most common symptoms included fatigue, sweating, chest tightness, anxiety, and myalgia. Older age (odds ratio [OR], 1.02; 95% CI, 1.01-1.02; P < .001), female sex (OR, 1.27; 95% CI, 1.06-1.52; P = .008), and severe disease during hospital stay (OR, 1.43; 95% CI, 1.18-1.74; P < .001) were associated with higher risks of fatigue. Older age (OR, 1.02; 95% CI, 1.01-1.03; P < .001) and severe disease (OR, 1.51; 95% CI, 1.14-1.99; P = .004) were associated with higher risks of having at least 3 symptoms. The median (IQR) CAT score was 2 (0-4), and a total of 161 patients (6.6%) had a CAT score of at least 10. Severe disease (OR, 1.84; 95% CI, 1.31-2.58; P < .001) and coexisting cerebrovascular diseases (OR, 1.95; 95% CI, 1.07-3.54; P = .03) were independent risk factors for CAT scores of at least 10. CONCLUSIONS AND RELEVANCE: This study found that patients with COVID-19 with severe disease during hospitalization had more postinfection symptoms and higher CAT scores. American Medical Association 2021-09-29 /pmc/articles/PMC8482055/ /pubmed/34586367 http://dx.doi.org/10.1001/jamanetworkopen.2021.27403 Text en Copyright 2021 Zhang X et al. JAMA Network Open. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the CC-BY License.
spellingShingle Original Investigation
Zhang, Xue
Wang, Fang
Shen, Ye
Zhang, Xiaohua
Cen, Yuan
Wang, Bin
Zhao, Songtao
Zhou, Yi
Hu, Baoman
Wang, Man
Liu, Yuhui
Miao, Hongming
Jones, Paul
Ma, Xiangyu
He, Yong
Cao, Guoqiang
Cheng, Lixia
Li, Li
Symptoms and Health Outcomes Among Survivors of COVID-19 Infection 1 Year After Discharge From Hospitals in Wuhan, China
title Symptoms and Health Outcomes Among Survivors of COVID-19 Infection 1 Year After Discharge From Hospitals in Wuhan, China
title_full Symptoms and Health Outcomes Among Survivors of COVID-19 Infection 1 Year After Discharge From Hospitals in Wuhan, China
title_fullStr Symptoms and Health Outcomes Among Survivors of COVID-19 Infection 1 Year After Discharge From Hospitals in Wuhan, China
title_full_unstemmed Symptoms and Health Outcomes Among Survivors of COVID-19 Infection 1 Year After Discharge From Hospitals in Wuhan, China
title_short Symptoms and Health Outcomes Among Survivors of COVID-19 Infection 1 Year After Discharge From Hospitals in Wuhan, China
title_sort symptoms and health outcomes among survivors of covid-19 infection 1 year after discharge from hospitals in wuhan, china
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482055/
https://www.ncbi.nlm.nih.gov/pubmed/34586367
http://dx.doi.org/10.1001/jamanetworkopen.2021.27403
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