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Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core
Background: This study aimed to validate the Brazilian version of EORTC CAT Core and compare the Brazilian results with those from the original European EORTC CAT Core validation study. Methods: After validated translation, 168 cancer patients from Brazil receiving radiation therapy with or without...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482129/ https://www.ncbi.nlm.nih.gov/pubmed/34590597 http://dx.doi.org/10.3390/curroncol28050291 |
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author | Marta, Gustavo Nader de Souza, Tomás Y. T. Silva, Alice R. N. de Souza e Pereira, Ana Paula A. Ferreira Neto, David R. Asso, Rie N. Degrande, Fabiana A. M. Nader-Marta, Guilherme da Silva, Maurício F. Gadia, Rafael Hanna, Samir A. Holzner, Bernhard Saad, Everardo D. Petersen, Morten Aagaard |
author_facet | Marta, Gustavo Nader de Souza, Tomás Y. T. Silva, Alice R. N. de Souza e Pereira, Ana Paula A. Ferreira Neto, David R. Asso, Rie N. Degrande, Fabiana A. M. Nader-Marta, Guilherme da Silva, Maurício F. Gadia, Rafael Hanna, Samir A. Holzner, Bernhard Saad, Everardo D. Petersen, Morten Aagaard |
author_sort | Marta, Gustavo Nader |
collection | PubMed |
description | Background: This study aimed to validate the Brazilian version of EORTC CAT Core and compare the Brazilian results with those from the original European EORTC CAT Core validation study. Methods: After validated translation, 168 cancer patients from Brazil receiving radiation therapy with or without chemotherapy was assessed. Translated EORTC CAT Core and all QLQ-C30 items were administered to patients using CHES (Computer-Based Health Evaluation System) before (T0) and after (T1) treatment initiation. The association between QLQ-C30 and CAT scores and ceiling/floor effects were estimated. Based on estimates of relative validity (cross-sectional, known-group differences and changes over time), relative sample-size requirements for CAT compared to QLQ-C30 were estimated. Results: Correlation coefficients between CAT and QLQ-C30 domains ranged from 0.63 to 0.93; except for dyspnoea, all coefficients were >0.82 (corresponding figures were 0.81–0.93 in the European study). On average across domains, floor/ceiling was reduced by 10% using CAT (9% in the European study) corresponding to a relative reduction of 32% (37% in the European study). Analyses of known-group validity and responsiveness indicated that, on average across domains, the sample-size requirements may be reduced by 17% using CAT rather than QLQ-C30, without loss of power (28% in the European study). The Brazilian sample had less symptom/quality of life impairment than the European sample, which likely explains the lower sample-size reduction using CAT when comparing with the European sample. Conclusions: The results in the Brazilian cohort were generally similar to those from the European sample and confirm the validity and usefulness of the EORTC CAT Core. |
format | Online Article Text |
id | pubmed-8482129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84821292021-10-01 Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core Marta, Gustavo Nader de Souza, Tomás Y. T. Silva, Alice R. N. de Souza e Pereira, Ana Paula A. Ferreira Neto, David R. Asso, Rie N. Degrande, Fabiana A. M. Nader-Marta, Guilherme da Silva, Maurício F. Gadia, Rafael Hanna, Samir A. Holzner, Bernhard Saad, Everardo D. Petersen, Morten Aagaard Curr Oncol Article Background: This study aimed to validate the Brazilian version of EORTC CAT Core and compare the Brazilian results with those from the original European EORTC CAT Core validation study. Methods: After validated translation, 168 cancer patients from Brazil receiving radiation therapy with or without chemotherapy was assessed. Translated EORTC CAT Core and all QLQ-C30 items were administered to patients using CHES (Computer-Based Health Evaluation System) before (T0) and after (T1) treatment initiation. The association between QLQ-C30 and CAT scores and ceiling/floor effects were estimated. Based on estimates of relative validity (cross-sectional, known-group differences and changes over time), relative sample-size requirements for CAT compared to QLQ-C30 were estimated. Results: Correlation coefficients between CAT and QLQ-C30 domains ranged from 0.63 to 0.93; except for dyspnoea, all coefficients were >0.82 (corresponding figures were 0.81–0.93 in the European study). On average across domains, floor/ceiling was reduced by 10% using CAT (9% in the European study) corresponding to a relative reduction of 32% (37% in the European study). Analyses of known-group validity and responsiveness indicated that, on average across domains, the sample-size requirements may be reduced by 17% using CAT rather than QLQ-C30, without loss of power (28% in the European study). The Brazilian sample had less symptom/quality of life impairment than the European sample, which likely explains the lower sample-size reduction using CAT when comparing with the European sample. Conclusions: The results in the Brazilian cohort were generally similar to those from the European sample and confirm the validity and usefulness of the EORTC CAT Core. MDPI 2021-08-31 /pmc/articles/PMC8482129/ /pubmed/34590597 http://dx.doi.org/10.3390/curroncol28050291 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Marta, Gustavo Nader de Souza, Tomás Y. T. Silva, Alice R. N. de Souza e Pereira, Ana Paula A. Ferreira Neto, David R. Asso, Rie N. Degrande, Fabiana A. M. Nader-Marta, Guilherme da Silva, Maurício F. Gadia, Rafael Hanna, Samir A. Holzner, Bernhard Saad, Everardo D. Petersen, Morten Aagaard Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core |
title | Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core |
title_full | Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core |
title_fullStr | Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core |
title_full_unstemmed | Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core |
title_short | Brazilian Validation of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) Computerised Adaptive Tests (CAT) Core |
title_sort | brazilian validation of the european organisation for research and treatment of cancer (eortc) quality of life group (qlg) computerised adaptive tests (cat) core |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482129/ https://www.ncbi.nlm.nih.gov/pubmed/34590597 http://dx.doi.org/10.3390/curroncol28050291 |
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