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New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas

Splenic marginal zone lymphoma (SMZL) is a small B-cell lymphoma, which has been recognized as a distinct pathological entity since the WHO 2008 classification. It classically presents an indolent evolution, but a third of patients progress rapidly and require aggressive treatments, such as immuno-c...

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Autores principales: Donzel, Marie, Baseggio, Lucile, Fontaine, Juliette, Pesce, Florian, Ghesquières, Hervé, Bachy, Emmanuel, Verney, Aurélie, Traverse-Glehen, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482189/
https://www.ncbi.nlm.nih.gov/pubmed/34590593
http://dx.doi.org/10.3390/curroncol28050297
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author Donzel, Marie
Baseggio, Lucile
Fontaine, Juliette
Pesce, Florian
Ghesquières, Hervé
Bachy, Emmanuel
Verney, Aurélie
Traverse-Glehen, Alexandra
author_facet Donzel, Marie
Baseggio, Lucile
Fontaine, Juliette
Pesce, Florian
Ghesquières, Hervé
Bachy, Emmanuel
Verney, Aurélie
Traverse-Glehen, Alexandra
author_sort Donzel, Marie
collection PubMed
description Splenic marginal zone lymphoma (SMZL) is a small B-cell lymphoma, which has been recognized as a distinct pathological entity since the WHO 2008 classification. It classically presents an indolent evolution, but a third of patients progress rapidly and require aggressive treatments, such as immuno-chemotherapy or splenectomy, with all associated side effects. In recent years, advances in the comprehension of SMZL physiopathology have multiplied, thanks to the arrival of new devices in the panel of available molecular biology techniques, allowing the discovery of new molecular findings. In the era of targeted therapies, an update of current knowledge is needed to guide future researches, such as those on epigenetic modifications or the microenvironment of these lymphomas.
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spelling pubmed-84821892021-10-01 New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas Donzel, Marie Baseggio, Lucile Fontaine, Juliette Pesce, Florian Ghesquières, Hervé Bachy, Emmanuel Verney, Aurélie Traverse-Glehen, Alexandra Curr Oncol Review Splenic marginal zone lymphoma (SMZL) is a small B-cell lymphoma, which has been recognized as a distinct pathological entity since the WHO 2008 classification. It classically presents an indolent evolution, but a third of patients progress rapidly and require aggressive treatments, such as immuno-chemotherapy or splenectomy, with all associated side effects. In recent years, advances in the comprehension of SMZL physiopathology have multiplied, thanks to the arrival of new devices in the panel of available molecular biology techniques, allowing the discovery of new molecular findings. In the era of targeted therapies, an update of current knowledge is needed to guide future researches, such as those on epigenetic modifications or the microenvironment of these lymphomas. MDPI 2021-09-06 /pmc/articles/PMC8482189/ /pubmed/34590593 http://dx.doi.org/10.3390/curroncol28050297 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Donzel, Marie
Baseggio, Lucile
Fontaine, Juliette
Pesce, Florian
Ghesquières, Hervé
Bachy, Emmanuel
Verney, Aurélie
Traverse-Glehen, Alexandra
New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas
title New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas
title_full New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas
title_fullStr New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas
title_full_unstemmed New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas
title_short New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas
title_sort new insights into the biology and diagnosis of splenic marginal zone lymphomas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482189/
https://www.ncbi.nlm.nih.gov/pubmed/34590593
http://dx.doi.org/10.3390/curroncol28050297
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