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Subungual Melanoma: A Single Institution Experience

Despite the changing paradigms of melanoma treatment in recent years, there remains a relative paucity of data regarding subungual melanoma in the literature. From 2002–2018, 25 patients with subungual melanoma were surgically treated at our facility. A retrospective chart review was conducted to co...

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Autores principales: LaRocca, Christopher J., Lai, Lily, Nelson, Rebecca A., Modi, Badri, Crawford, Brooke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482220/
https://www.ncbi.nlm.nih.gov/pubmed/34564082
http://dx.doi.org/10.3390/medsci9030057
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author LaRocca, Christopher J.
Lai, Lily
Nelson, Rebecca A.
Modi, Badri
Crawford, Brooke
author_facet LaRocca, Christopher J.
Lai, Lily
Nelson, Rebecca A.
Modi, Badri
Crawford, Brooke
author_sort LaRocca, Christopher J.
collection PubMed
description Despite the changing paradigms of melanoma treatment in recent years, there remains a relative paucity of data regarding subungual melanoma in the literature. From 2002–2018, 25 patients with subungual melanoma were surgically treated at our facility. A retrospective chart review was conducted to collect relevant demographic, clinical, pathologic, and outcomes data. The median age at diagnosis was 69 years. Most patients (60%) were male, and the melanoma lesion was most often located on the foot (68%). Acral-lentiginous was the most common histologic subtype (59%), and the median Breslow thickness was 3.4 mm. Fifteen patients (63%) underwent a sentinel lymph node biopsy as part of their surgical resection, and four of these patients (27%) had metastatic disease in the lymph nodes. In total, 10 patients underwent lymph node dissection of the involved basin. The median follow up was 21 months in this patient population. Age, gender, tumor location, ulceration, and lesion histology were not significantly associated with recurrence free survival (RFS). Increasing Breslow thickness was found to be significantly associated with shorter RFS (HR: 1.07, CI: 1.03–1.55). In total, 13 patients developed a disease recurrence, and RFS rates were 66% at 1 year and 40% at 3 years. Additionally, 91 and 37% of patients were alive at one year and three years, respectively. Subungual melanomas are rare lesions that often have a more advanced stage at diagnosis, which contributes to the poor prognosis of these cutaneous malignancies.
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spelling pubmed-84822202021-10-01 Subungual Melanoma: A Single Institution Experience LaRocca, Christopher J. Lai, Lily Nelson, Rebecca A. Modi, Badri Crawford, Brooke Med Sci (Basel) Article Despite the changing paradigms of melanoma treatment in recent years, there remains a relative paucity of data regarding subungual melanoma in the literature. From 2002–2018, 25 patients with subungual melanoma were surgically treated at our facility. A retrospective chart review was conducted to collect relevant demographic, clinical, pathologic, and outcomes data. The median age at diagnosis was 69 years. Most patients (60%) were male, and the melanoma lesion was most often located on the foot (68%). Acral-lentiginous was the most common histologic subtype (59%), and the median Breslow thickness was 3.4 mm. Fifteen patients (63%) underwent a sentinel lymph node biopsy as part of their surgical resection, and four of these patients (27%) had metastatic disease in the lymph nodes. In total, 10 patients underwent lymph node dissection of the involved basin. The median follow up was 21 months in this patient population. Age, gender, tumor location, ulceration, and lesion histology were not significantly associated with recurrence free survival (RFS). Increasing Breslow thickness was found to be significantly associated with shorter RFS (HR: 1.07, CI: 1.03–1.55). In total, 13 patients developed a disease recurrence, and RFS rates were 66% at 1 year and 40% at 3 years. Additionally, 91 and 37% of patients were alive at one year and three years, respectively. Subungual melanomas are rare lesions that often have a more advanced stage at diagnosis, which contributes to the poor prognosis of these cutaneous malignancies. MDPI 2021-09-15 /pmc/articles/PMC8482220/ /pubmed/34564082 http://dx.doi.org/10.3390/medsci9030057 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
LaRocca, Christopher J.
Lai, Lily
Nelson, Rebecca A.
Modi, Badri
Crawford, Brooke
Subungual Melanoma: A Single Institution Experience
title Subungual Melanoma: A Single Institution Experience
title_full Subungual Melanoma: A Single Institution Experience
title_fullStr Subungual Melanoma: A Single Institution Experience
title_full_unstemmed Subungual Melanoma: A Single Institution Experience
title_short Subungual Melanoma: A Single Institution Experience
title_sort subungual melanoma: a single institution experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482220/
https://www.ncbi.nlm.nih.gov/pubmed/34564082
http://dx.doi.org/10.3390/medsci9030057
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