Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment

Regulatory T cells (Treg cells) are critical mediators of self-tolerance, but they can also limit effective anti-tumor immunity. Although under homeostasis a small fraction of Treg cells in lymphoid organs express the putative checkpoint molecule Tim-3, this protein is expressed by a much larger pro...

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Detalles Bibliográficos
Autores principales: Banerjee, Hridesh, Nieves-Rosado, Hector, Kulkarni, Aditi, Murter, Benjamin, McGrath, Kyle V., Chandran, Uma R., Chang, Alexander, Szymczak-Workman, Andrea L., Vujanovic, Lazar, Delgoffe, Greg M., Ferris, Robert L., Kane, Lawrence P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482289/
https://www.ncbi.nlm.nih.gov/pubmed/34525351
http://dx.doi.org/10.1016/j.celrep.2021.109699

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