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A Native Mass Spectrometry-Based Assay for Rapid Assessment of the Empty:Full Capsid Ratio in Adeno-Associated Virus Gene Therapy Products

[Image: see text] Adeno-associated virus (AAV)-based gene therapy is a rapidly developing field, requiring analytical methods for detailed product characterization. One important quality attribute of AAV products that requires monitoring is the amount of residual empty capsids following downstream p...

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Detalles Bibliográficos
Autores principales:	Strasser, Lisa, Morgan, Tomos E., Guapo, Felipe, Füssl, Florian, Forsey, Daniel, Anderson, Ian, Bones, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482367/ https://www.ncbi.nlm.nih.gov/pubmed/34519199 http://dx.doi.org/10.1021/acs.analchem.1c02828

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