Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes—a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC–MS

[Image: see text] Histone acetylation is an important, reversible post-translational protein modification and a hallmark of epigenetic regulation. However, little is known about the dynamics of this process, due to the lack of analytical methods that can capture site-specific acetylation and deacety...

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Detalles Bibliográficos
Autores principales: van Pijkeren, Alienke, Dietze, Jörn, Brotons, Alejandro Sánchez, Egger, Anna-Sophia, Lijster, Tim, Barcaru, Andrei, Hotze, Madlen, Kobler, Philipp, Dekker, Frank J., Horvatovich, Peter, Melgert, Barbro N., Ziegler, Mathias, Thedieck, Kathrin, Heiland, Ines, Bischoff, Rainer, Kwiatkowski, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482368/
https://www.ncbi.nlm.nih.gov/pubmed/34519498
http://dx.doi.org/10.1021/acs.analchem.1c01359

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