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Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease
Cholinergic deficits are a hallmark of Alzheimer’s disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482375/ https://www.ncbi.nlm.nih.gov/pubmed/33413710 http://dx.doi.org/10.1017/S1041610220003944 |
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author | Schumacher, Julia Thomas, Alan J. Peraza, Luis R. Firbank, Michael O’Brien, John T. Taylor, John-Paul |
author_facet | Schumacher, Julia Thomas, Alan J. Peraza, Luis R. Firbank, Michael O’Brien, John T. Taylor, John-Paul |
author_sort | Schumacher, Julia |
collection | PubMed |
description | Cholinergic deficits are a hallmark of Alzheimer’s disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in neurodegenerative diseases. Forty-six LBD patients, 29 AD patients, and 31 healthy age-matched controls underwent resting-state functional magnetic resonance imaging (fMRI). A seed-based analysis was applied with seeds in the left and right NBM to assess functional connectivity between the NBM and the rest of the brain. We found a shift from anticorrelation in controls to positive correlations in LBD between the right/left NBM and clusters in right/left occipital cortex. Our results indicate that there is an imbalance in functional connectivity between the NBM and primary visual areas in LBD, which provides new insights into alterations within a part of the corticopetal cholinergic system that go beyond structural changes. |
format | Online Article Text |
id | pubmed-8482375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84823752021-10-08 Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease Schumacher, Julia Thomas, Alan J. Peraza, Luis R. Firbank, Michael O’Brien, John T. Taylor, John-Paul Int Psychogeriatr Brief Report Cholinergic deficits are a hallmark of Alzheimer’s disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in neurodegenerative diseases. Forty-six LBD patients, 29 AD patients, and 31 healthy age-matched controls underwent resting-state functional magnetic resonance imaging (fMRI). A seed-based analysis was applied with seeds in the left and right NBM to assess functional connectivity between the NBM and the rest of the brain. We found a shift from anticorrelation in controls to positive correlations in LBD between the right/left NBM and clusters in right/left occipital cortex. Our results indicate that there is an imbalance in functional connectivity between the NBM and primary visual areas in LBD, which provides new insights into alterations within a part of the corticopetal cholinergic system that go beyond structural changes. Cambridge University Press 2021-01 2021-01-08 /pmc/articles/PMC8482375/ /pubmed/33413710 http://dx.doi.org/10.1017/S1041610220003944 Text en © International Psychogeriatric Association 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Schumacher, Julia Thomas, Alan J. Peraza, Luis R. Firbank, Michael O’Brien, John T. Taylor, John-Paul Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease |
title | Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease |
title_full | Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease |
title_fullStr | Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease |
title_full_unstemmed | Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease |
title_short | Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease |
title_sort | functional connectivity of the nucleus basalis of meynert in lewy body dementia and alzheimer’s disease |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482375/ https://www.ncbi.nlm.nih.gov/pubmed/33413710 http://dx.doi.org/10.1017/S1041610220003944 |
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