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Immunohistochemical differences in gastric mucosal damage between nodular and non-nodular gastritis caused by Helicobacter pylori infection
In this study, the level of cell damage were analyzed immunohistochemically to clarify the association between nodular gastritis and undifferentiated gastric cancer. Thirty patients of nodular gastritis were enrolled as the nodular gastritis group. Thirty patients of non-nodular gastritis were enro...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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the Society for Free Radical Research Japan
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482388/ https://www.ncbi.nlm.nih.gov/pubmed/34616112 http://dx.doi.org/10.3164/jcbn.20-179 |
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author | Okamoto, Kazuhisa Kodama, Masaaki Mizukami, Kazuhiro Okimoto, Tadayoshi Abe, Hisanori Ogawa, Ryo Fukuda, Kensuke Matsunari, Osamu Hirashita, Yuka Wada, Yasuhiro Fukuda, Masahide Murakami, Kazunari |
author_facet | Okamoto, Kazuhisa Kodama, Masaaki Mizukami, Kazuhiro Okimoto, Tadayoshi Abe, Hisanori Ogawa, Ryo Fukuda, Kensuke Matsunari, Osamu Hirashita, Yuka Wada, Yasuhiro Fukuda, Masahide Murakami, Kazunari |
author_sort | Okamoto, Kazuhisa |
collection | PubMed |
description | In this study, the level of cell damage were analyzed immunohistochemically to clarify the association between nodular gastritis and undifferentiated gastric cancer. Thirty patients of nodular gastritis were enrolled as the nodular gastritis group. Thirty patients of non-nodular gastritis were enrolled as the control group. They were evaluated according to the updated Sydney system and used for immunohistochemical staining (p53, Ki-67, E-cadherin, and 8-OHdG). The scores based on the updated Sydney system were significantly higher in the nodular group than in the non-nodular group for histologically assessed inflammation and activity in the gastric corpus (1.91 ± 0.77 vs 1.58 ± 0.60, p = 0.049, 0.83 ± 0.81 vs 0.44 ± 0.64, p = 0.032). On immunostaining, the detection of E-cadherin was lower in the nodular group for both the antrum (1.0 ± 0.62 vs 1.47 ± 0.85, p = 0.047) and the corpus (1.16 ± 0.81 vs 1.48 ± 0.71, p = 0.043) and the p53 labeling index of the gastric corpus was higher in the nodular group than in the non-nodular group (3.06 ± 1.94 vs 2.03 ± 1.99, p = 0.015). Nodular gastritis showed significant severe inflammation and immunohistochemical cell damage compared with non-nodular gastritis. These findings may play an important role in the oncogenesis of undifferentiated gastric cancer in nodular gastritis. |
format | Online Article Text |
id | pubmed-8482388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | the Society for Free Radical Research Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-84823882021-10-05 Immunohistochemical differences in gastric mucosal damage between nodular and non-nodular gastritis caused by Helicobacter pylori infection Okamoto, Kazuhisa Kodama, Masaaki Mizukami, Kazuhiro Okimoto, Tadayoshi Abe, Hisanori Ogawa, Ryo Fukuda, Kensuke Matsunari, Osamu Hirashita, Yuka Wada, Yasuhiro Fukuda, Masahide Murakami, Kazunari J Clin Biochem Nutr Original Article In this study, the level of cell damage were analyzed immunohistochemically to clarify the association between nodular gastritis and undifferentiated gastric cancer. Thirty patients of nodular gastritis were enrolled as the nodular gastritis group. Thirty patients of non-nodular gastritis were enrolled as the control group. They were evaluated according to the updated Sydney system and used for immunohistochemical staining (p53, Ki-67, E-cadherin, and 8-OHdG). The scores based on the updated Sydney system were significantly higher in the nodular group than in the non-nodular group for histologically assessed inflammation and activity in the gastric corpus (1.91 ± 0.77 vs 1.58 ± 0.60, p = 0.049, 0.83 ± 0.81 vs 0.44 ± 0.64, p = 0.032). On immunostaining, the detection of E-cadherin was lower in the nodular group for both the antrum (1.0 ± 0.62 vs 1.47 ± 0.85, p = 0.047) and the corpus (1.16 ± 0.81 vs 1.48 ± 0.71, p = 0.043) and the p53 labeling index of the gastric corpus was higher in the nodular group than in the non-nodular group (3.06 ± 1.94 vs 2.03 ± 1.99, p = 0.015). Nodular gastritis showed significant severe inflammation and immunohistochemical cell damage compared with non-nodular gastritis. These findings may play an important role in the oncogenesis of undifferentiated gastric cancer in nodular gastritis. the Society for Free Radical Research Japan 2021-09 2021-03-25 /pmc/articles/PMC8482388/ /pubmed/34616112 http://dx.doi.org/10.3164/jcbn.20-179 Text en Copyright © 2021 JCBN https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Original Article Okamoto, Kazuhisa Kodama, Masaaki Mizukami, Kazuhiro Okimoto, Tadayoshi Abe, Hisanori Ogawa, Ryo Fukuda, Kensuke Matsunari, Osamu Hirashita, Yuka Wada, Yasuhiro Fukuda, Masahide Murakami, Kazunari Immunohistochemical differences in gastric mucosal damage between nodular and non-nodular gastritis caused by Helicobacter pylori infection |
title | Immunohistochemical differences in gastric mucosal damage between nodular and non-nodular gastritis caused by Helicobacter pylori infection |
title_full | Immunohistochemical differences in gastric mucosal damage between nodular and non-nodular gastritis caused by Helicobacter pylori infection |
title_fullStr | Immunohistochemical differences in gastric mucosal damage between nodular and non-nodular gastritis caused by Helicobacter pylori infection |
title_full_unstemmed | Immunohistochemical differences in gastric mucosal damage between nodular and non-nodular gastritis caused by Helicobacter pylori infection |
title_short | Immunohistochemical differences in gastric mucosal damage between nodular and non-nodular gastritis caused by Helicobacter pylori infection |
title_sort | immunohistochemical differences in gastric mucosal damage between nodular and non-nodular gastritis caused by helicobacter pylori infection |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482388/ https://www.ncbi.nlm.nih.gov/pubmed/34616112 http://dx.doi.org/10.3164/jcbn.20-179 |
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