N-acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization

There are five known general catalytic mechanisms used by enzymes to catalyze carbohydrate epimerization. The amino sugar epimerase N-acetylmannosamine-6-phosphate 2-epimerase (NanE) has been proposed to use a deprotonation–reprotonation mechanism, with an essential catalytic lysine required for bot...

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Detalles Bibliográficos
Autores principales: Currie, Michael J., Manjunath, Lavanyaa, Horne, Christopher R., Rendle, Phillip M., Subramanian, Ramaswamy, Friemann, Rosmarie, Fairbanks, Antony J., Muscroft-Taylor, Andrew C., North, Rachel A., Dobson, Renwick C.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482478/
https://www.ncbi.nlm.nih.gov/pubmed/34437902
http://dx.doi.org/10.1016/j.jbc.2021.101113

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